Effect of Demineralized Bone Matrix on Bone Growth within a Porous HA Material: A Histologic and Histometric Study

Coralline hydroxyapatite (cHA) is an osteoconductive material currently being used as a bone graft substitute. Created by the hydrothermal conversion of the calcium carbonate skeleton of coral to hydroxyapatite, this material has a porous structure similar to cancellous bone. Addition of demineraliz...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biomaterials applications 1995-01, Vol.9 (3), p.275-288
Main Authors: Damien, Christopher J., Parsons, J. Russell, Preweit, Annamarie B., Huismans, Frank, Shors, Edwin C., Holmes, Ralph E.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Bone Demineralization Technique
Bone Matrix - ultrastructure
Bone Substitutes
Ceramics
Durapatite
Materials Testing
Medical sciences
Microscopy, Electron
Osseointegration
Prostheses and Implants
Rabbits
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Random Allocation
Skull - surgery
Surface Properties
Technology. Biomaterials. Equipments. Material. Instrumentation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Coralline hydroxyapatite (cHA) is an osteoconductive material currently being used as a bone graft substitute. Created by the hydrothermal conversion of the calcium carbonate skeleton of coral to hydroxyapatite, this material has a porous structure similar to cancellous bone. Addition of demineralized bone matrix (DBM) would conceivably create a composite with both osteoconductive and osteoinductive properties. This pilot study evaluated the healing of rabbit cranial defects that had been filled with cHA or cHA augmented with a DBM gel formed by adding glycerol to the DBM particulate. Data from these were then compared to unfilled defects from a previous study. Results indicated enhancement of new bone formation and an increase in the rate of healing in the defects filled with the cHA-DBM gel composite. Further studies are warranted.
ISSN:0885-3282
1530-8022
DOI:10.1177/088532829500900306