Dose-responses for the slowing of gastric emptying in a rodent model by glucagon-like peptide (7-36)NH2, amylin, cholecystokinin, and other possible regulators of nutrient uptake

Several peptides have been proposed as regulators of nutrient release from the stomach and subsequent uptake from the gut. Using a phenol red gavage method, we compared the potencies of subcutaneously preinjected amylin, glucagon-like peptide-1 (7-36)amide (GLP-1), cholecystokinin octapeptide (CCK-8...

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Bibliographic Details
Published in:Metabolism, clinical and experimental clinical and experimental, 1996-01, Vol.45 (1), p.1-3
Main Authors: Young, A.A. (Amylin Pharmaceuticals, San Diego, CA), Gedulin, B.R, Rink, T.J
Format: Article
Language:English
Subjects:
Amino Acids - pharmacokinetics
Amyloid - pharmacology
Animals
Biological and medical sciences
Cholecystokinin - pharmacology
DIGESTION
DOSAGE EFFECTS
Dose-Response Relationship, Drug
ESTOMAC
ESTOMAGO
Functional investigation of the digestive system
Gastric Emptying - drug effects
Gastric Emptying - physiology
Gastric Inhibitory Polypeptide - pharmacology
GASTRIC INHIBITORY POLYPEPTIDES
GASTROINTESTINAL HORMONES
Gastrointestinal Hormones - pharmacology
Gels
GLUCAGON
Glucagon - pharmacology
Glucagon-Like Peptide 1
Glucagon-Like Peptides
Glucose - pharmacokinetics
HORMONAS GASTROINTESTINALES
HORMONE GASTROINTESTINALE
INHIBICION
INHIBITION
Investigative techniques, diagnostic techniques (general aspects)
Islet Amyloid Polypeptide
Male
Medical sciences
Pancreatic Polypeptide - pharmacology
PANCREOZYMIN
PEPTIDE
Peptide Fragments - pharmacology
PEPTIDES
PEPTIDOS
Phenolsulfonphthalein
RAT
RATA
RATS
Rats, Sprague-Dawley
STOMACH
STOMACH EMPTYING
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Description
Summary:Several peptides have been proposed as regulators of nutrient release from the stomach and subsequent uptake from the gut. Using a phenol red gavage method, we compared the potencies of subcutaneously preinjected amylin, glucagon-like peptide-1 (7-36)amide (GLP-1), cholecystokinin octapeptide (CCK-8), gastric inhibitory peptide (GIP), glucagon, and pancreatic peptide on slowing the release of an acaloric gel from rat stomach. The latter three peptides did not fully inhibit gastric emptying at subcutaneous doses up to 100 micrograms. Amylin, GLP-1, and CCK-8 fully inhibited gastric emptying, with ED50s of 0.42 +/- 0.07, 6.1 +/- 0.12, and 8.5 +/- 0.20 nmol/kg +/- SE of log, respectively.
ISSN:0026-0495
1532-8600
DOI:10.1016/S0026-0495(96)90192-4