Mild hypothermia increases blood loss and transfusion requirements during total hip arthroplasty

Summary Background In-vitro studies indicate that platelet function and the coagulation cascade are impaired by hypothermia. However, the extent to which perioperative hypothermia influences bleeding during surgery remains unknown. Accordingly, we tested the hypothesis that mild hypothermia increase...

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Bibliographic Details
Published in:The Lancet (British edition) 1996-02, Vol.347 (8997), p.289-292
Main Authors: Schmied, H, Reiter, A, Kurz, A, Sessler, D.I, Kozek, S
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Analysis of Variance
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Biomedical materials
Bleeding
Blood
Blood Loss, Surgical - statistics & numerical data
Blood transfusion
Blood Transfusion - statistics & numerical data
Blood transfusions
Core loss
Emergency and intensive postoperative care (general aspects). Pathophysiology of surgery
Female
Hip
Hip joint
Hip Prosthesis
Humans
Hypothermia
Hypothermia, Induced - adverse effects
Intensive care medicine
Joint surgery
Male
Medical sciences
Middle Aged
Patients
Surgery
Surgical implants
Total hip arthroplasty
Transfusion
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Summary:Summary Background In-vitro studies indicate that platelet function and the coagulation cascade are impaired by hypothermia. However, the extent to which perioperative hypothermia influences bleeding during surgery remains unknown. Accordingly, we tested the hypothesis that mild hypothermia increases blood loss and allogeneic transfusion requirements during hip arthroplasty. Methods Blood loss and transfusion requirements were evaluated in 60 patients undergoing primary, unilateral total hip arthroplasties who were randomly assigned to normothermia (final intraoperative core temperature 36·6 [0·4]°C) or mild hypothermia (35·0 [0·5]°C). Crystalloid, colloid, scavenged red cells, and allogeneic blood were administered by strict protocol. Findings Intra- and postoperative blood loss was significantly greater in the hypothermic patients: 2·2 (0·5) L vs 1·7 (0·3) L, p
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(96)90466-3