Ambulatory monitoring uncorrected for placebo overestimates long-term antihypertensive action. Systolic Hypertension in Europe (SYST-EUR) Trial Investigators

This study compares blood pressure (BP) changes during active antihypertensive treatment and placebo as assessed by conventional and ambulatory BP measurement. Older patients (> or = 60 years, n=337) with isolated systolic hypertension by conventional sphygmomanometry at the clinic were randomize...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1996-03, Vol.27 (3 Pt 1), p.414-420
Main Authors: Staessen, J A, Thijs, L, Bieniaszewski, L, O'Brien, E T, Palatini, P, Davidson, C, Dobovisek, J, Jääskivi, M, Laks, T, Lehtonen, A, Vanhanen, H, Webster, J, Fagard, R
Format: Article
Language:English
Subjects:
Aged
Antihypertensive Agents - therapeutic use
Blood Pressure
Double-Blind Method
Enalapril - therapeutic use
Female
Humans
Hydrochlorothiazide - therapeutic use
Hypertension - diagnosis
Hypertension - drug therapy
Male
Middle Aged
Monitoring, Ambulatory
Nitrendipine - therapeutic use
Placebos
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Summary:This study compares blood pressure (BP) changes during active antihypertensive treatment and placebo as assessed by conventional and ambulatory BP measurement. Older patients (> or = 60 years, n=337) with isolated systolic hypertension by conventional sphygmomanometry at the clinic were randomized to placebo or active treatment consisting of nitrendipine (10 to 40 mg/d), with the possible addition of enalapril (5 to 20 mg/d) and/or hydrochlorothiazide (12.5 to 25 mg/d). At baseline, clinic systolic/diastolic BP averaged 175/86 mm Hg and 24-hour and daytime ambulatory BPs averaged 148/80 and 154/85 mm Hg, respectively. After 13 months (median) of active treatment, clinic BP had dropped by 22.7/7.0 mm Hg and 24-hour and daytime BPs by 10.5/4.5 and 9.7/4.3 mm Hg, respectively (P
ISSN:0194-911X