Electrocardiographic measurement of infarct size after thrombolytic therapy

• Published in: Journal of the American College of Cardiology 1996-03, Vol.27 (3), p.617-624
• Main Authors: Juergens, Craig P., Fernades, Clyne, Hasche, Edmund T., Meikle, Steven, Bautovich, George, Currie, Colin A., Ben Freedman, S., Jeremy, Richmond W.
• Format: Article
• Language: English
• Subjects: Aged; Biological and medical sciences; Cardiology. Vascular system; Coronary heart disease; Drug Monitoring; Electrocardiography; Female; Heart; Humans; Male; Medical sciences; Middle Aged; Myocardial Infarction - diagnosis; Myocardial Infarction - drug therapy; Prognosis; Prospective Studies; Radionuclide Ventriculography; Reproducibility of Results; Risk Factors; Severity of Illness Index; Stroke Volume; Thrombolytic Therapy; Time Factors; Tomography, Emission-Computed, Single-Photon
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/0735-1097(95)00497-1

Objectives.We examined the utility of the 32-point QRS score from the 12-lead electrocardiogram (ECG) for measurement of the ischemic risk region and infarct size in patients receiving thrombolytic therapy. Background.The QRS score offers a means of evaluating the therapeutic benefit of thrombolytic therapy by comparing final infarct size with the initial extent of ischemic myocardium. Methods.The study included 38 patients (34 men, 4 women; mean [±SD] age 54 ± 10 years) with a first infarction (18 anterior, 20 inferior). The maximal potential QRS score (QRS0) was assigned to all leads with ≥ 100-μV ST elevation on the initial ECG. The QRS scores were calculated at 7 and 30 days after infarction. Left ventricular ejection fraction was measured by radionuclide ventriculography at 1 month. Twenty-eight patients had thallium (T1)-201 and technetium (Tc)-99m pyrophosphate tomographic measurement of the ischemic region and infarct size. Results.The QRS0was 10.3 ± 3.1 (mean ± SD) for anterior and 10.4 ± 3.5 for inferior infarcts. The QRS scores were similar at 7 and 30 days for both anterior (5.6 ± 3.4 vs. 5.5 ± 3.4) and inferior infarcts (3.7 ± 2.6 vs. 2.9 ± 2.2). The day 7 QRS score and ejection fraction at 1 month were inversely correlated (r = −0.74, p < 0.01). The T1-201 perfusion defect was 34 ± 11% of the left ventricle for anterior and 32 ± 7% for inferior infarcts. Subsequent Tc-99m pyrophosphate infarct size was 15 ± 9% of the left ventricle for anterior and 17 ± 9% for inferior infarcts. The QRS0was correlated with the extent of the T1-201 perfusion defect (r = 0.79, p < 0.001), and the day 7 QRS score was correlated with Tc-99m pyrophosphate infarct size (r = 0.79, p < 0.005). Conclusions.The 32-point QRS score can provide useful immediate measurements of the ischemic risk region and subsequent infarct size.