Seropositivity in Liver Transplant Recipients as a Predictor of Cytomegalovirus Disease

Infections with cytomegalovirus (CMV), are asymptomatic in most individuals. CMV is a latent virus, and the potential for reactivation exists. Organ transplant recipients are at increased risk for developing symptomatic CMV infection due to the immunosuppressive therapy that is required for successf...

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Bibliographic Details
Published in:The Journal of infectious diseases 1988-02, Vol.157 (2), p.383-385
Main Authors: Fox, Amy S., Tolpin, Mark D., Baker, Alfred L., Broelsch, Christoph E., Whittington, Peter F., Jackson, Timothy, Thistlethwaite, J. Richard, Stuart, Frank P.
Format: Article
Language:English
Subjects:
Antibodies, Viral - analysis
Biological and medical sciences
Concise Communications
Cyclosporins
Cytomegalovirus
Cytomegalovirus - immunology
Cytomegalovirus infections
Cytomegalovirus Infections - etiology
Cytomegalovirus Infections - immunology
Disease risk
Human viral diseases
Humans
Immunoglobulin G - analysis
Immunosuppression
Infections
Infectious diseases
Liver
Liver Transplantation
Medical sciences
Retrospective Studies
Transplantation
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viremia
Viruses
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Summary:Infections with cytomegalovirus (CMV), are asymptomatic in most individuals. CMV is a latent virus, and the potential for reactivation exists. Organ transplant recipients are at increased risk for developing symptomatic CMV infection due to the immunosuppressive therapy that is required for successful engraftment. In renal transplant recipients, CMV infection has been implicated as a cause of early-onset graft rejection; such rejection may result from direct effects of CMV on cellular immunity or reduction of the patient's immunosuppressive therapy in an attempt to control viral disease. The patient at highest risk is the seronegative recipient of a kidney from a donor seropositive for CMV. To determine the influence of donor and recipient seropositivity on the incidence of CMV disease in immunosuppressed liver transplant patients, the authors retrospectively examined CMV serostatus in liver donors and recipients and the development of subsequent CMV disease in these transplant recipients.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/157.2.383