Etiology of rickets in Nigerian children

We studied 26 Nigerian children with active rickets (13 boys, 13 girls), aged 1 to 5 years, and compared results of biochemical studies with those of healthy control subjects. The plasma 1,25-dihydroxyvitamin D level was elevated (568 ± 317 pmol/L) and the 25-hydroxyvitamin D level was low (36 ± 28...

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Bibliographic Details
Published in:The Journal of pediatrics 1996-05, Vol.128 (5), p.692-694
Main Authors: Oginni, L.M., Worsfold, M., Oyelami, O.A., Sharp, C.A., Powell, D.E., Davie, M.W.J.
Format: Article
Language:English
Subjects:
Biological and medical sciences
CALCIO
CALCIUM
Calcium - blood
Calcium - deficiency
CARENCE EN SUBSTANCE NUTRITIVE
CARENCE EN VITAMINE
Case-Control Studies
Child, Preschool
COMPOSICION DE LA SANGRE
COMPOSITION DU SANG
DEFICIENCIA DE VITAMINAS
DEFICIENCIAS NUTRITIVAS
ENCUESTAS
ENFANT
ENQUETE
ETIOLOGIA
ETIOLOGIE
Female
Humans
Infant
Male
Medical sciences
Metabolic diseases
NIGERIA
Nigeria - epidemiology
NINOS
Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)
PLASMA SANGUIN
PLASMA SANGUINEO
RACHITISME
RAQUITISMO
Rickets - blood
Rickets - epidemiology
Rickets - etiology
Tropical medicine
Vitamin D Deficiency - blood
Vitamin D Deficiency - complications
VITAMINA D
VITAMINE D
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Summary:We studied 26 Nigerian children with active rickets (13 boys, 13 girls), aged 1 to 5 years, and compared results of biochemical studies with those of healthy control subjects. The plasma 1,25-dihydroxyvitamin D level was elevated (568 ± 317 pmol/L) and the 25-hydroxyvitamin D level was low (36 ± 28 nmol/L) in the children with rickets compared with the control subjects (369 ± 134 nmol/L and 69 ± 22 nmol/L, respectively). The results suggest that rickets in Nigeria is largely the result of calcium deficiency and that vitamin D deficiency and possibly end organ resistance may be contributory factors.
ISSN:0022-3476
1097-6833
DOI:10.1016/S0022-3476(96)80137-5