Propofol permits tracheal intubation but does not affect postoperative myalgias

Study Objective: To determine the effect of propofol without succinylcholine on intubating conditions and postoperative myalgias in ambulatory surgical patients undergoing general anesthesia. Design: Prospective, double-blind, randomized study. Setting: Ambulatory surgery adult patients. Patients: 5...

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Bibliographic Details
Published in:Journal of clinical anesthesia 1996-05, Vol.8 (3), p.220-224
Main Authors: Mingus, Melinda L., Shamsi, Adiba K., Recant, Jane F., Eisenkraft, James B.
Format: Article
Language:English
Subjects:
Adult
Ambulatory Surgical Procedures
Anesthesia, outpatient
Anesthetics, Intravenous
anesthetics, intravenous, propofol
complications, muscle pain
Double-Blind Method
Drug Therapy, Combination
Female
Humans
Intubation, Intratracheal
intubation, tracheal
Male
Muscular Diseases - prevention & control
Neuromuscular Depolarizing Agents - therapeutic use
neuromuscular relaxants, succinylcholine
Pain, Postoperative - prevention & control
Propofol
Prospective Studies
Succinylcholine - therapeutic use
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Summary:Study Objective: To determine the effect of propofol without succinylcholine on intubating conditions and postoperative myalgias in ambulatory surgical patients undergoing general anesthesia. Design: Prospective, double-blind, randomized study. Setting: Ambulatory surgery adult patients. Patients: 56 ASA physical status I and II adult patients undergoing general endotracheal anesthesia. Interventions: Group 1 patients received thiamylal plus sucdnylcholine, Group 2 patients recdved propofol plus sucdnylcholine; and Group 3 patients received propofol plus saline. All patients received fentanyl, lidocaine, and nitrous oxide plus isoflurane in oxygen. Measurements and Main Results: Incidence and severity of fasciculations, tracheal intubating conditions, and myalgias on the first and third postoperative days were measured. Propofol did not affect the incidence or severity of fasciculations following sucdnylcholine, or the incidence of myalgias. Of patients who received propofol without succinylcholine, intubation was successful in 85%. Conclusions: Propofol did not affect the incidence or severity of postoperative myalgias following succinylcholine.
ISSN:0952-8180
1873-4529
DOI:10.1016/0952-8180(95)00234-0