Histamine release from mast cells and monocytes: the effects of azelastine, reproterol and vitamin A-analogues

In addition to basophils, monocytes and lymphocytes are important sources of histamine in blood which may be released on stimulation with either A 23187, C5a or substance P. This release may be inhibited significantly by high concentrations of disodium cromoglycate (DSCG) but not by ketotifen. Free...

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Bibliographic Details
Published in:Inflammation research 1996-03, Vol.45 Suppl 1 (S1), p.S5-S6
Main Authors: Bolsmann, K, Braam, U, Eichelberg, D, Greven, T, Jungbluth, C, Schmutzler, W, Zwadlo-Klarwasser, G
Format: Article
Language:English
Subjects:
Adrenergic beta-Agonists - pharmacology
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Antioxidants - pharmacology
beta Carotene
Carotenoids - pharmacology
Dose-Response Relationship, Drug
Drug Combinations
Etretinate - pharmacology
Histamine H1 Antagonists - pharmacology
Histamine Release - drug effects
Humans
Isotretinoin - pharmacology
Keratolytic Agents - pharmacology
Mast Cells - drug effects
Mast Cells - metabolism
Metaproterenol - analogs & derivatives
Metaproterenol - pharmacology
Monocytes - drug effects
Monocytes - metabolism
Phthalazines - pharmacology
Quinolines - pharmacology
Superoxide Dismutase - pharmacology
Theophylline - analogs & derivatives
Theophylline - pharmacology
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Summary:In addition to basophils, monocytes and lymphocytes are important sources of histamine in blood which may be released on stimulation with either A 23187, C5a or substance P. This release may be inhibited significantly by high concentrations of disodium cromoglycate (DSCG) but not by ketotifen. Free radicals have been shown to originate from monocytes and to activate mast cells. This might be an important process in inflammatory reactions. Therefore we tested the effects of some radical scavengers, e.g. superoxide dismutase (SOD), two dihydrochinolines (MG and MDS), beta -carotene and two vitamin A-analogues (isotretinoin and etretinate) on the histamine release induced by Con A from human adenoidal mast cells. beta -Carotene was also tested in C5a-stimulated human peripheral blood monocytes. The H sub(1)-blocker azelastine and the beta sub(2)-agonist reproterol were included in the study for comparison.
ISSN:1023-3830
1420-908X
DOI:10.1007/BF03354062