Massive synchronous B-cell necrosis causing type 1 (insulin-dependent) diabetes, a unique histopathological case report

A 22-year-old Chinese male died in hyperglycaemic coma following a 36-h illness. The only significant pathological findings were in the pancreas where there was a heavy diffuse infiltrate of lymphocytes admixed with numerous eosinophils, macrophages and polymorphs. There appeared to have been massiv...

Full description

Saved in:
Bibliographic Details
Published in:Diabetologia 1988, Vol.31 (1), p.46-50
Main Authors: FOULIS, A. K, FRANCIS, N. D, FARQUHARSON, M. A, BOYLSTON, A
Format: Article
Language:English
Subjects:
Acute-Phase Reaction - pathology
Adult
Associated diseases and complications
Biological and medical sciences
Diabetes Mellitus, Type 1 - etiology
Diabetes Mellitus, Type 1 - pathology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Humans
Hyperglycemia - etiology
Inflammation - pathology
Islets of Langerhans - pathology
Male
Medical sciences
Necrosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A 22-year-old Chinese male died in hyperglycaemic coma following a 36-h illness. The only significant pathological findings were in the pancreas where there was a heavy diffuse infiltrate of lymphocytes admixed with numerous eosinophils, macrophages and polymorphs. There appeared to have been massive, recent, synchronous necrosis of insulin-secreting B cells with no destruction of any other pancreatic parenchymal cells. The biochemical findings of severe hyperglycaemia, insulinopoenia, but a normal glycosylated HbA1 were compatible with an acute onset to the patient's diabetes. These features contrast with the very much slower destruction of B cells associated with insulitis seen in "classical" Type 1 (insulin-dependent) diabetes.
ISSN:0012-186X
1432-0428
DOI:10.1007/BF00279132