INCIDENCE AND GEOGRAPHIC DISTRIBUTION OF SEROLOGICALLY VERIFIED CASES OF NEPHROPATHIA EPIDEMICA IN SWEDEN

A nationwide survey of hospitalized, seroiogically verified adult nephropathia epidemics cases in Sweden from 1978 to 1981 was performed. Serum was collected from 1,063 patients with a diagnosis of nephropathia epidemica or one of 10 other renal diseases with related symptoms. Sera were analyzed by...

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Bibliographic Details
Published in:American journal of epidemiology 1988-04, Vol.127 (4), p.801-807
Main Authors: SETTERGREN, BO, JUTO, PER, WADELL, GÖRAN, TROLLFORS, BIRGER, NORRBY, S. RAGNAR
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Antibodies, Viral - analysis
Biological and medical sciences
epidemic
Female
Glomerulonephritis
Hantaan virus
Hantavirus - immunology
hemorrhagic fever
Hemorrhagic Fever with Renal Syndrome - epidemiology
Hemorrhagic Fever with Renal Syndrome - immunology
Humans
Immunoglobulin G - analysis
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
rodent diseases
Sweden
virus diseases
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Summary:A nationwide survey of hospitalized, seroiogically verified adult nephropathia epidemics cases in Sweden from 1978 to 1981 was performed. Serum was collected from 1,063 patients with a diagnosis of nephropathia epidemica or one of 10 other renal diseases with related symptoms. Sera were analyzed by indirect immunofluorescence technique for the presence of immunoglobulln G antibodies to Hantaan virus, causative agent of Korean hemorrhagic fever that cross-reacts with the nephropathia epidemics agent Antibodies were present in 388 patients, 355 of whom also fulfilled four or more of six criteria for clinical diagnosis of nephropathia epidemica. The male:female ratio was 2.7:1. The total number of cases In Sweden varied between 26 and 144 per year, which coincided with the fluctuations in small rodent populations. The highest incidence was found in Västerbotten County, with a maximum crude incidence rate of 23.5 cases per 100,000 Inhabitants per year. Mean crude incidence in Sweden during the study period was 1.3 cases per 100,000 inhabitants per year. The southernmost cases lived in proximity to the 59th parallel. Thus, nephropathia epidemics was found to be prevalent south of the 60th parallel, which was previously assumed to be its southern boundary.
ISSN:0002-9262
1476-6256
DOI:10.1093/oxfordjournals.aje.a114862