The Chromosomal Mapping of Four Genes Encoding Winged Helix Proteins Expressed Early in Mouse Development

Members of the winged helix family of transcription factors are required for the normal embryonic development of the mouse. Using the interspecific backcross panel from The Jackson Laboratory, we have determined the chromosomal locations of four genes that encode winged helix containing proteins.Mf1...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 1996-06, Vol.34 (2), p.241-245
Main Authors: Labosky, Patricia A., Winnier, Glenn E., Sasaki, Hiroshi, Blessing, Manfred, Hogan, Brigid L.M.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chromosome Mapping
Classical genetics, quantitative genetics, hybrids
Crosses, Genetic
DNA Probes
DNA, Complementary
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Developmental
Genetic Markers
Genetics of eukaryotes. Biological and molecular evolution
Genomic Library
Mice - genetics
Mice, Mutant Strains
Multigene Family
Muridae
Restriction Mapping
Transcription Factors - biosynthesis
Transcription Factors - genetics
Vertebrata
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Summary:Members of the winged helix family of transcription factors are required for the normal embryonic development of the mouse. Using the interspecific backcross panel from The Jackson Laboratory, we have determined the chromosomal locations of four genes that encode winged helix containing proteins.Mf1was assigned to mouse Chromosome 8,Mf2to Chromosome 4,Mf3to Chromosome 9, andMf4to Chromosome 13. SinceMf3is located in a region of Chromosome 9 containing many well-characterized mouse mutations such asshort ear(se),ashen(ash), anddilute(d), we have analyzed deletion mutants to determine the location ofMf3more precisely.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.1996.0275