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Hair iron content: possible marker to complement monitoring therapy of iron deficiency in patients with chronic inflammatory bowel diseases?
Measurements of the concentration of iron in hair from 10 patients with chronic inflammatory bowel diseases and from 10 healthy controls showed that the iron concentrations were significantly (P < 0.05) lower in patients before iron intake than in controls. Three weeks after beginning iron treatm...
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Published in: | Clinical chemistry (Baltimore, Md.) Md.), 1996-08, Vol.42 (8), p.1270-1274 |
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container_title | Clinical chemistry (Baltimore, Md.) |
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creator | Bisse, E Renner, F Sussmann, S Scholmerich, J Wieland, H |
description | Measurements of the concentration of iron in hair from 10 patients with chronic inflammatory bowel diseases and from 10 healthy controls showed that the iron concentrations were significantly (P < 0.05) lower in patients before iron intake than in controls. Three weeks after beginning iron treatment, the hair iron concentrations were found to be significantly correlated (r = 0.68; P < 0.05) to reticulocyte counts. Changes in the hair iron concentrations were accompanied by similar changes in the concentrations of the markers most commonly used to diagnose and monitor iron deficiency. The results suggest that quantification of hair iron may be useful to complement evaluations of the body iron status. |
doi_str_mv | 10.1093/clinchem/42.8.1270 |
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Three weeks after beginning iron treatment, the hair iron concentrations were found to be significantly correlated (r = 0.68; P < 0.05) to reticulocyte counts. Changes in the hair iron concentrations were accompanied by similar changes in the concentrations of the markers most commonly used to diagnose and monitor iron deficiency. The results suggest that quantification of hair iron may be useful to complement evaluations of the body iron status.</description><identifier>ISSN: 0009-9147</identifier><identifier>EISSN: 1530-8561</identifier><identifier>DOI: 10.1093/clinchem/42.8.1270</identifier><identifier>PMID: 8697588</identifier><identifier>CODEN: CLCHAU</identifier><language>eng</language><publisher>Washington, DC: Am Assoc Clin Chem</publisher><subject>Biological and medical sciences ; Biomarkers ; Chronic Disease ; Colitis, Ulcerative - complications ; Crohn Disease - complications ; Ferritins - blood ; Gastroenterology. Liver. Pancreas. Abdomen ; Hair - chemistry ; Hair - metabolism ; Humans ; Inflammatory Bowel Diseases - complications ; Iron - analysis ; Iron - deficiency ; Iron - therapeutic use ; Kinetics ; Medical sciences ; Other diseases. Semiology ; Reticulocyte Count ; Stomach. Duodenum. Small intestine. Colon. Rectum. 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Three weeks after beginning iron treatment, the hair iron concentrations were found to be significantly correlated (r = 0.68; P < 0.05) to reticulocyte counts. Changes in the hair iron concentrations were accompanied by similar changes in the concentrations of the markers most commonly used to diagnose and monitor iron deficiency. The results suggest that quantification of hair iron may be useful to complement evaluations of the body iron status.</description><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Chronic Disease</subject><subject>Colitis, Ulcerative - complications</subject><subject>Crohn Disease - complications</subject><subject>Ferritins - blood</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hair - chemistry</subject><subject>Hair - metabolism</subject><subject>Humans</subject><subject>Inflammatory Bowel Diseases - complications</subject><subject>Iron - analysis</subject><subject>Iron - deficiency</subject><subject>Iron - therapeutic use</subject><subject>Kinetics</subject><subject>Medical sciences</subject><subject>Other diseases. Semiology</subject><subject>Reticulocyte Count</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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Liver. Pancreas. Abdomen</topic><topic>Hair - chemistry</topic><topic>Hair - metabolism</topic><topic>Humans</topic><topic>Inflammatory Bowel Diseases - complications</topic><topic>Iron - analysis</topic><topic>Iron - deficiency</topic><topic>Iron - therapeutic use</topic><topic>Kinetics</topic><topic>Medical sciences</topic><topic>Other diseases. Semiology</topic><topic>Reticulocyte Count</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Transferrin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bisse, E</creatorcontrib><creatorcontrib>Renner, F</creatorcontrib><creatorcontrib>Sussmann, S</creatorcontrib><creatorcontrib>Scholmerich, J</creatorcontrib><creatorcontrib>Wieland, H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical chemistry (Baltimore, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bisse, E</au><au>Renner, F</au><au>Sussmann, S</au><au>Scholmerich, J</au><au>Wieland, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hair iron content: possible marker to complement monitoring therapy of iron deficiency in patients with chronic inflammatory bowel diseases?</atitle><jtitle>Clinical chemistry (Baltimore, Md.)</jtitle><addtitle>Clin Chem</addtitle><date>1996-08-01</date><risdate>1996</risdate><volume>42</volume><issue>8</issue><spage>1270</spage><epage>1274</epage><pages>1270-1274</pages><issn>0009-9147</issn><eissn>1530-8561</eissn><coden>CLCHAU</coden><abstract>Measurements of the concentration of iron in hair from 10 patients with chronic inflammatory bowel diseases and from 10 healthy controls showed that the iron concentrations were significantly (P < 0.05) lower in patients before iron intake than in controls. Three weeks after beginning iron treatment, the hair iron concentrations were found to be significantly correlated (r = 0.68; P < 0.05) to reticulocyte counts. Changes in the hair iron concentrations were accompanied by similar changes in the concentrations of the markers most commonly used to diagnose and monitor iron deficiency. The results suggest that quantification of hair iron may be useful to complement evaluations of the body iron status.</abstract><cop>Washington, DC</cop><pub>Am Assoc Clin Chem</pub><pmid>8697588</pmid><doi>10.1093/clinchem/42.8.1270</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Biological and medical sciences Biomarkers Chronic Disease Colitis, Ulcerative - complications Crohn Disease - complications Ferritins - blood Gastroenterology. Liver. Pancreas. Abdomen Hair - chemistry Hair - metabolism Humans Inflammatory Bowel Diseases - complications Iron - analysis Iron - deficiency Iron - therapeutic use Kinetics Medical sciences Other diseases. Semiology Reticulocyte Count Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Transferrin - metabolism |
title | Hair iron content: possible marker to complement monitoring therapy of iron deficiency in patients with chronic inflammatory bowel diseases? |
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