Killing of Giardia lamblia Trophozoites by Human Intestinal Fluid in Vitro

Because the upper small intestine is the major site of lipolysis, the authors examined whether intestinal fluid is toxic to G. lamblia and, if so, whether other factors promote survival. Aspirates of proximal intestinal fluid from uninfected humans kill G. lamblia trophozoites in vitro. Mucus and bi...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of infectious diseases 1988-06, Vol.157 (6), p.1257-1260
Main Authors: Das, Siddhartha, Reiner, David S., Zenian, John, Hogan, Daniel L., Koss, Michael A., Wang, Chi-Sun, Gillin, Frances D.
Format: Article
Language:English
Subjects:
Animals
Bile
Bile acids
Bile Acids and Salts - physiology
Biological and medical sciences
Concise Clinical and Laboratory Communications
Duodenum
Fasting
Fatty acids
Fatty Acids, Nonesterified - analysis
Fundamental and applied biological sciences. Psychology
Giardia - immunology
Giardia - physiology
Giardiasis
Humans
Intestinal Secretions - analysis
Intestinal Secretions - physiology
Jejunum
Life cycle. Host-agent relationship. Pathogenesis
Lipase - analysis
Lipolysis
Mucus
Nonesterified fatty acids
Protozoa
Trophozoites
Trypsin - analysis
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Because the upper small intestine is the major site of lipolysis, the authors examined whether intestinal fluid is toxic to G. lamblia and, if so, whether other factors promote survival. Aspirates of proximal intestinal fluid from uninfected humans kill G. lamblia trophozoites in vitro. Mucus and bile salts, however, above their critical micellar concentration (CMC) interfere with killing and may promote specific colonization of the small intestine by G. lamblia .
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/157.6.1257