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Inactivated Marburg virus elicits a nonprotective immune response in Rhesus monkeys
In the present work the kinetics of some indices of immunity (tumor necrosis factor (TNF), interferon (IFN), natural killer cells (NK), lymphocyte proliferation activity, virus-specific antibodies, CD4/CD8 ratio) in response to Marburg virus infection in Macaca mulatta were studied. The different ki...
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| Published in: | Journal of biotechnology 1996-01, Vol.44 (1), p.111-118 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c419t-5fa3761fa035972a3d3f19b5b506dc1f35bbda91e6b4584a80b0f601d1ba6cb03 |
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| cites | cdi_FETCH-LOGICAL-c419t-5fa3761fa035972a3d3f19b5b506dc1f35bbda91e6b4584a80b0f601d1ba6cb03 |
| container_end_page | 118 |
| container_issue | 1 |
| container_start_page | 111 |
| container_title | Journal of biotechnology |
| container_volume | 44 |
| creator | Ignatyev, George M. Agafonov, Alexander P. Streltsova, Marina A. Kashentseva, Elena A. |
| description | In the present work the kinetics of some indices of immunity (tumor necrosis factor (TNF), interferon (IFN), natural killer cells (NK), lymphocyte proliferation activity, virus-specific antibodies, CD4/CD8 ratio) in response to Marburg virus infection in
Macaca mulatta were studied. The different kinetics of immunological parameters for animals which survived Marburg virus infection and for animals which died after infection are shown. A comparison of the indices of IFN, TNF and spontaneous lymphocyte proliferation activity in
Macaca mulatta infected with Marburg virus at different stages of life shows the relationship between the increase of these indices and the decrease in the animals' lifespan. Marburg virus immunosuppressive properties were corroborated by studying lymphocyte proliferation activity in response to antigenic stimulation in vitro and the CD4/CD8 index during experimental Marburg virus infection in
Macaca mulatta. We conclude that the disease outcome depends on the dynamics of certain immunologie indices such as TNF and IFN. |
| doi_str_mv | 10.1016/0168-1656(95)00104-2 |
| format | article |
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Macaca mulatta were studied. The different kinetics of immunological parameters for animals which survived Marburg virus infection and for animals which died after infection are shown. A comparison of the indices of IFN, TNF and spontaneous lymphocyte proliferation activity in
Macaca mulatta infected with Marburg virus at different stages of life shows the relationship between the increase of these indices and the decrease in the animals' lifespan. Marburg virus immunosuppressive properties were corroborated by studying lymphocyte proliferation activity in response to antigenic stimulation in vitro and the CD4/CD8 index during experimental Marburg virus infection in
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Macaca mulatta were studied. The different kinetics of immunological parameters for animals which survived Marburg virus infection and for animals which died after infection are shown. A comparison of the indices of IFN, TNF and spontaneous lymphocyte proliferation activity in
Macaca mulatta infected with Marburg virus at different stages of life shows the relationship between the increase of these indices and the decrease in the animals' lifespan. Marburg virus immunosuppressive properties were corroborated by studying lymphocyte proliferation activity in response to antigenic stimulation in vitro and the CD4/CD8 index during experimental Marburg virus infection in
Macaca mulatta. 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Macaca mulatta were studied. The different kinetics of immunological parameters for animals which survived Marburg virus infection and for animals which died after infection are shown. A comparison of the indices of IFN, TNF and spontaneous lymphocyte proliferation activity in
Macaca mulatta infected with Marburg virus at different stages of life shows the relationship between the increase of these indices and the decrease in the animals' lifespan. Marburg virus immunosuppressive properties were corroborated by studying lymphocyte proliferation activity in response to antigenic stimulation in vitro and the CD4/CD8 index during experimental Marburg virus infection in
Macaca mulatta. We conclude that the disease outcome depends on the dynamics of certain immunologie indices such as TNF and IFN.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>8717394</pmid><doi>10.1016/0168-1656(95)00104-2</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of biotechnology, 1996-01, Vol.44 (1), p.111-118 |
| issn | 0168-1656 1873-4863 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78266103 |
| source | Elsevier:Jisc Collections:Elsevier Read and Publish Agreement 2022-2024:Freedom Collection (Reading list) |
| subjects | AIDS/HIV Animals Antibodies, Viral - biosynthesis Antibodies, Viral - blood Antibody Formation Biotechnology CD4-CD8 Ratio Guinea Pigs Immune response Interferons - biosynthesis Killer Cells, Natural - immunology Kinetics Lymphocyte Activation Lymphocyte proliferation Macaca mulatta Marburg virus Marburg Virus Disease - immunology Marburg Virus Disease - prevention & control Marburgvirus - immunology Mediator of immunity Time Factors Tumor Necrosis Factor-alpha - biosynthesis Vaccines, Inactivated Viral Vaccines Virus antibody |
| title | Inactivated Marburg virus elicits a nonprotective immune response in Rhesus monkeys |
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