STUDY OF THE USEFULNESS OF A KIT CONTAINING IMIPENEM/CILASTATIN POWDER WITH DILUENT FOR INJECTION: ACCURACY OF RECONSTITUTION

• Published in: Japanese journal of antibiotics 1996/02/25, Vol.49(2), pp.211-217
• Main Authors: HIRAYAMA, TAKESHI, KUROYAMA, MASAKAZU, SHIMADA, SHIGEHIKO
• Format: Article
• Language: Japanese
• Subjects: Cilastatin; Drug Packaging; Drug Therapy, Combination; Humans; Imipenem; Injections; Polyenes; Powders; Protease Inhibitors; Quality Control; Sodium Chloride; Syringes; Thienamycins
• ISSN: 0368-2781; 2186-5477
• DOI: 10.11553/antibiotics1968b.49.211

The usefulness of a kit consisting of non-glass packaging was evaluated in terms of accuracy of reconstitution. The newly developed imipenem/cilastatin powder-and-diluent kit consists of a polyolefin bag with two chambers that contain imipenem/cilastatin powder and diluent (0.9% saline, 100 ml), respectively. The accuracy of reconstitution was determined by nurses and pharmacists at the Kitasato University East Hospital by measuring the amount of materials remaining in vials after reconstitution using the syringe dilution method and the transfer-needle dilution method. The mean percent amounts of imipenem and cilastatin remaining after preparation by the syringe dilution method were 5.58±2.60% and 4.08±1.77%, respectively. The mean percent amounts of imipenem and cilastatin remaining after preparation by the transfer-needle dilution method were 3.99±2.28% and 3.71±2.09%, respectively. The amount of imipenem/cilastatin remaining in the newly developed kit should be negligible, because the kit serves as both a vial and a dosing package. Therefore, greater accuracy in terms of reconstitution is expected with the newly developed kit than with the traditional syringe dilution or transfer-needle dilution methods.