Termination of second trimester pregnancy with gemeprost and misoprostol: A randomized double-blind placebo-controlled trial

A prospective randomized double-blind placebo-controlled trial was conducted in 70 subjects to determine whether pre-treatment with misoprostol could facilitate termination of second trimester pregnancy by gemeprost. The women received either 400 μg oral misoprostol or placebo tablets 12 hours befor...

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Bibliographic Details
Published in:Contraception (Stoneham) 1996-07, Vol.54 (1), p.23-25
Main Authors: Wong, K.S., Ngai, C.S.W., Chan, K.S., Tang, L.C.H., Ho, P.C.
Format: Article
Language:English
Subjects:
Abortion, Induced
Administration, Intravaginal
Administration, Oral
Adolescent
Adult
Alprostadil - administration & dosage
Alprostadil - adverse effects
Alprostadil - analogs & derivatives
Biological and medical sciences
Birth control
Double-Blind Method
Female
gemeprost
Gynecology. Andrology. Obstetrics
Humans
Induced abortion. Therapeutic abortion
Medical sciences
Misoprostol - administration & dosage
Misoprostol - adverse effects
oral misoprostol
Placebos
Population
Pregnancy
Pregnancy Trimester, Second
second trimester termination
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Summary:A prospective randomized double-blind placebo-controlled trial was conducted in 70 subjects to determine whether pre-treatment with misoprostol could facilitate termination of second trimester pregnancy by gemeprost. The women received either 400 μg oral misoprostol or placebo tablets 12 hours before the administration of vaginal pessary of gemeprost 1 mg every 3 hours. There were no significant differences in induction-abortion interval and the amount of gemeprost required between the misoprostol and the placebo group. There was no significant difference in the incidence of side effects or analgesic requirement between the two groups. We conclude that oral misoprostol is not useful in facilitating termination of second trimester pregnancy by gemeprost.
ISSN:0010-7824
1879-0518
DOI:10.1016/0010-7824(96)00115-1