Isoflurane and large coronary artery haemodynamics: a study in dogs

In the dog, stepped increases in isoflurane concentration (up to 1.5 MAC) caused peripheral and coronary vasodilatation. In the presence of significant decreases in arterial pressure (-35%), contractility (-46%), cardiac output (-17%) and coronary perfusion pressure (-40%), coronary blood flow remai...

Full description

Saved in:
Bibliographic Details
Published in:British journal of anaesthesia : BJA 1988-06, Vol.60 (7), p.784-790
Main Authors: CUTFIELD, G. R, FRANCIS, C. M, FOEX, P, JONES, L. A, RYDER, W. A
Format: Article
Language:English
Subjects:
Anesthesia, Inhalation
Anesthetics. Neuromuscular blocking agents
Animals
Biological and medical sciences
Blood Pressure - drug effects
Constriction
Coronary Circulation - drug effects
Coronary Vessels - drug effects
Coronary Vessels - physiology
Dogs
Hemodynamics - drug effects
Isoflurane - metabolism
Isoflurane - pharmacology
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Pulmonary Alveoli - metabolism
Vascular Resistance - drug effects
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In the dog, stepped increases in isoflurane concentration (up to 1.5 MAC) caused peripheral and coronary vasodilatation. In the presence of significant decreases in arterial pressure (-35%), contractility (-46%), cardiac output (-17%) and coronary perfusion pressure (-40%), coronary blood flow remained unchanged, while the effective coronary vascular resistance was halved. The coronary reserve, estimated by the hyperaemic response to short periods (10 s) of coronary occlusion was reduced by the stepped increases in isoflurane concentration. Linear relationships were observed between peak hyperaemic flow, volume repayment, repayment: deficit ratio and coronary perfusion pressure. The vasodilation induced by isoflurane was of such magnitude that, at 1.5 MAC, the repayment: deficit ratio was close to unity, indicating that the vasodilatory reserve was almost exhausted.
ISSN:0007-0912
1471-6771