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Intrauterine programming of hypertension: nutrient-hormone interactions

Geographic, retrospective, and prospective epidemiologic studies have revealed evidence that the environment in utero is a major determinant of later degenerative disease. Observations from Britain, Sweden, Jamaica, Australia, India, and China support the hypothesis that disproportionate retardation...

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Bibliographic Details
Published in:Nutrition reviews 1996-06, Vol.54 (6), p.163-169
Main Authors: Langley-Evans, S. (University of Southampton, Southampton, UK.), Jackson, A
Format: Article
Language:English
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Summary:Geographic, retrospective, and prospective epidemiologic studies have revealed evidence that the environment in utero is a major determinant of later degenerative disease. Observations from Britain, Sweden, Jamaica, Australia, India, and China support the hypothesis that disproportionate retardation of fetal growth results in increased blood pressure and increased risk of cardiovascular mortality. On the basis of what has been a limited pool of observations linking maternal undernutrition and fetal growth retardation, it has been proposed that hypertension and coronary heart disease are "programmed" by nutrition status
ISSN:0029-6643
1753-4887
DOI:10.1111/j.1753-4887.1996.tb03923.x