Enterotoxigenic Escherichia coli Associated Diarrhoea among Infants Aged Less than Six Months in Calcutta, India

The role of enterotoxigenic Escherichia coli (ETEC) as etiologic agents of diarrhoea in infants aged less than six months was assessed in a hospital based study in Calcutta, India. Of the 218 cases examined, ETEC strains were isolated from 26 (11.9%) cases. Among these, in 17 cases ETEC was the sole...

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Bibliographic Details
Published in:European journal of epidemiology 1996-02, Vol.12 (1), p.81-84
Main Authors: Ghosh, A. R., Koley, H., De, D., Paul, M., Nair, G. B., Sen, D.
Format: Article
Language:English
Subjects:
Adults
Anti-Bacterial Agents - pharmacology
Antibiotics
Antigens
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Biological and medical sciences
Brief Reports
Cohort Studies
Diarrhea
Diarrhea, Infantile - microbiology
Drug Resistance, Multiple
Enterotoxins
Epidemiology
Escherichia coli
Escherichia coli - classification
Escherichia coli - drug effects
Escherichia coli - pathogenicity
Escherichia coli Infections - microbiology
Female
Human bacterial diseases
Humans
Infant
Infectious diseases
Male
Medical sciences
Microbial colonization
Microbial Sensitivity Tests
Pathogens
Serotyping
Toxins
Tropical medicine
Ungulates
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Summary:The role of enterotoxigenic Escherichia coli (ETEC) as etiologic agents of diarrhoea in infants aged less than six months was assessed in a hospital based study in Calcutta, India. Of the 218 cases examined, ETEC strains were isolated from 26 (11.9%) cases. Among these, in 17 cases ETEC was the sole infecting pathogen (p = 0.0085). Of the 26 isolates (each isolate representing a case), 24 were distributed among seven different O:K:H serotypes and two different colonization factor antigens (CFAs) I and II. Two of the remaining isolation were untypable, non-haemagglutinating, and were non-hydrophobic as measured by the salt aggregation test (SAT). Of the 26 ETEC strains detected, 15 (57.7%) produced heat-labile toxin (LT) only, 8 (30.8%) liberated heat-stable toxin (ST) only, and the remaining 3 (11.5%) produced both LT and ST. No ETEC strain was isolated from the 102 age-matched controls included in this study. All the ETEC isolates were multiple drug resistant. The study showed that the diarrhoea due to ETEC was of brief duration, mostly within the range of 3 to 7 days.
ISSN:0393-2990
0392-2990
1573-7284
DOI:10.1007/BF00144433