Biotin deficiency may alter tibiotarsal bone growth and modeling in broiler chicks

Forty-eight, day-old male broiler chicks (Hubbard x Hubbard strain) were fed purified diets with two levels of biotin (0 and 400 micrograms/kg) and two levels of linoleate (26.5 and 1.5 g/kg) in a factorially designed experiment to determine the effects of these nutrients on tibiotarsal bone growth...

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Bibliographic Details
Published in:Poultry science 1988-04, Vol.67 (4), p.590-595
Main Authors: Bain, S.D, Newbrey, J.W, Watkins, B.A
Format: Article
Language:English
Subjects:
ALIMENTACION DE LOS ANIMALES
ALIMENTATION DES ANIMAUX
ANIMAL FEEDING
Animals
BIOTIN
Biotin - deficiency
BIOTINA
BIOTINE
BONE FORMATION
BROILER CHICKENS
CARENCE EN VITAMINES
Chickens - growth & development
CHICKS
DEFICIENCIA DE VITAMINAS
DESEMPENO
FORMACION OSEA
FORMATION DES OS
Hindlimb - abnormalities
HUESOS DE LOS MIEMBROS
LIMB BONES
Male
OS DES MEMBRES
POLLITO
POLLO DE ENGORDE
POULET DE CHAIR
Poultry Diseases - etiology
POUSSIN
Tarsus, Animal - abnormalities
Tibia - abnormalities
VITAMIN DEFICIENCIES
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Summary:Forty-eight, day-old male broiler chicks (Hubbard x Hubbard strain) were fed purified diets with two levels of biotin (0 and 400 micrograms/kg) and two levels of linoleate (26.5 and 1.5 g/kg) in a factorially designed experiment to determine the effects of these nutrients on tibiotarsal bone growth and modeling. Chicks fed biotin-deficient diets (0 microgram/kg diet) exhibited varus deformities, footpad dermatitis, shortened tibiotarsi, and significantly higher bone densities and percentage bone ash. Anatomically there were two different bone modeling patterns. The mid-diaphyseal cortex was thickest laterally in chicks fed adequate biotin and thickest medially in biotin-deficient chicks. Periosteal bone appositional and bone formation rates, osteoid perimeter, and osteoid area of perimeter were reduced in tibiotarsi of chicks fed diets deficient in biotin compared with effects in chicks fed adequate biotin. Altered bone modeling patterns and quantitative differences in bone histomorphometry suggest a relationship between the effects of biotin on bone growth and the development of varus limb deformities.
ISSN:0032-5791
1525-3171
DOI:10.3382/ps.0670590