Renin stimulates decidual prostaglandin production via a novel mechanism that is independent of angiotensin II formation

Renin is a proteolytic enzyme that has been considered to have only one function which is to cleave angiotensinogen between the 10th and 11th amino acids to form angiotensin-1. This is then converted to angiotensin-II, a potent vasoconstrictor, antinatriuretic and antidiuretic by angiotensin-convert...

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Bibliographic Details
Published in:Placenta (Eastbourne) 1996-07, Vol.17 (5), p.299-305
Main Authors: Mitchell, M.D., Edwin, S.S., Pollard, J.K., Trautman, M.S.
Format: Article
Language:English
Subjects:
Amnion - drug effects
Amnion - metabolism
Angiotensin II - biosynthesis
Angiotensin-Converting Enzyme Inhibitors - pharmacology
Arachidonic Acid - pharmacology
Biological and medical sciences
Cycloheximide - pharmacology
Dactinomycin - pharmacology
Decidua - drug effects
Decidua - metabolism
Dinoprostone - biosynthesis
Enzyme Induction - drug effects
Female
Fundamental and applied biological sciences. Psychology
Hormone metabolism and regulation
Humans
Pregnancy
Pregnancy. Parturition. Lactation
Prostaglandin-Endoperoxide Synthases - biosynthesis
Prostaglandins - biosynthesis
Protein Synthesis Inhibitors - pharmacology
Renin - pharmacology
Saralasin - pharmacology
Vertebrates: reproduction
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Summary:Renin is a proteolytic enzyme that has been considered to have only one function which is to cleave angiotensinogen between the 10th and 11th amino acids to form angiotensin-1. This is then converted to angiotensin-II, a potent vasoconstrictor, antinatriuretic and antidiuretic by angiotensin-converting enzyme. We have investigated the action of renin to stimulate prostaglandin production by decidual cells and in so doing have generated data that challenge the prevailing dogma. Renin stimulates decidual prostaglandin production in a concentration-related fashion that is unaffected by saralasin treatment. This stimulatory action of renin is enhanced rather than reduced by arachidonic acid treatment but abolished by treatment with cycloheximide or actinomycin D. Renin caused a more rapid recovery of decidual prostaglandin biosynthesis from acetylsalicylic acid treatment than did control media. Moreover, renin treatment of both decidual and amnion cells induced increased levels of PGHS-2 within 2 h. Collectively, these results indicate that renin can act directly, separately from the generation of angiotensin-I and II. In this case renin can induce PGHS expression.
ISSN:0143-4004
1532-3102
DOI:10.1016/S0143-4004(96)90053-3