Memory Modulation by Post-training Glucose or Insulin Remains Evident at Long Retention Intervals

Immediate posttraining intraperitoneal injection of α-D[+]-glucose (30 mg/kg) facilitated, whereas a nonconvulsive dose of insulin (8 IU/kg) impaired, 24-h retention, in male Swiss mice, of a one-trial step-through inhibitory avoidance task. When mice were trained and received immediate post-trainin...

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Bibliographic Details
Published in:Neurobiology of learning and memory 1996-03, Vol.65 (2), p.189-191
Main Authors: Kopf, Silvia R., Baratti, Carlos M.
Format: Article
Language:English
Subjects:
Animals
Behavioral psychophysiology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Glucose - pharmacology
Hormones and behavior
Insulin - pharmacology
Male
Mice
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Retention (Psychology) - drug effects
Sodium Chloride - pharmacology
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Summary:Immediate posttraining intraperitoneal injection of α-D[+]-glucose (30 mg/kg) facilitated, whereas a nonconvulsive dose of insulin (8 IU/kg) impaired, 24-h retention, in male Swiss mice, of a one-trial step-through inhibitory avoidance task. When mice were trained and received immediate post-training glucose or insulin injections and were tested for retention either 1 week or 1 month later, at each retention interval performance was comparable to that found with a 24-h retention interval. Thus, memory modulation by post-training administration of either glucose or insulin remain evident at long retention intervals.
ISSN:1074-7427
1095-9564
DOI:10.1006/nlme.1996.0020