Distribution of muscarinic receptor subtypes in rat brain from postnatal to old age

In an effort to understand the developmental changes in the distribution of muscarinic receptor subtypes (m1–m5), specific brain regions from juvenile (16-day-old), young (21-day-old) and adult (91-day-old) rats were analyzed using subtype-selective antibodies. These studies revealed significant age...

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Bibliographic Details
Published in:Brain research. Developmental brain research 1996-03, Vol.92 (1), p.70-76
Main Authors: Tice, Melissa A.B., Hashemi, Tanaz, Taylor, Lisa A., McQuade, Robert D.
Format: Article
Language:English
Subjects:
Aging - metabolism
Animals
Animals, Newborn - metabolism
Antibody
Brain
Brain - growth & development
Brain - metabolism
Central nervous system
CHO Cells
Cricetinae
Development
Humans
Immunoprecipitation
Muscarinic receptor
Precipitin Tests
Rats
Receptors, Muscarinic - metabolism
Tissue Distribution
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Summary:In an effort to understand the developmental changes in the distribution of muscarinic receptor subtypes (m1–m5), specific brain regions from juvenile (16-day-old), young (21-day-old) and adult (91-day-old) rats were analyzed using subtype-selective antibodies. These studies revealed significant age-dependent changes in the four brain regions examined. In cortex, and area associated with higher cognitive functions, significant increases of m2 and m4 receptors occurred between juvenile and adult rats. In the striatum, the level of m4 receptor increased with age whereas the m1, m2 and m3 receptors had reached mature levels within the first 16 days. Small but significant changes occured in the cerebellum with a decrease in m1, m3 and m4 receptor subtypes. In contrast to other brain regions, the hippocampus displayed consistent expression levels of muscarinic receptor subtypes. Suggesting that this brain region, which is involved in the foundation of numerous neural networks, requires a full complement of muscarinic receptors at a very early age. Muscarinic receptors have been shown to be important in a number of behavioral activities, including learning and memory. The changes observed in the age-dependent expression of these receptors most likely play an important role in how acetylcholine produces its effects in vivo.
ISSN:0165-3806
DOI:10.1016/0165-3806(95)01515-9