Duodenogastric Reflux of Intestinal Infusions in Rats is Volume Dependent

Experiments employing infusions of nutrients into the gastrointestinal tract commonly deliver large volumes of solutions without evaluating the possibility that reflux of the infusate to more orad sites may occur. To assess this possibility for one conventional paradigm, rats with gastric fistulas a...

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Bibliographic Details
Published in:Appetite 1996-08, Vol.27 (1), p.79-90
Main Authors: PHILLIPS, ROBERT J., WALLS, ELWOOD K., POWLEY, TERRY L.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Catheters, Indwelling
Coloring Agents
Duodenogastric Reflux - etiology
Duodenogastric Reflux - physiopathology
Duodenum
Enteral Nutrition
Fundamental and applied biological sciences. Psychology
Gastric Fistula
Intestine. Mesentery
Male
Rats
Rats, Sprague-Dawley
Solutions
Vertebrates: digestive system
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Summary:Experiments employing infusions of nutrients into the gastrointestinal tract commonly deliver large volumes of solutions without evaluating the possibility that reflux of the infusate to more orad sites may occur. To assess this possibility for one conventional paradigm, rats with gastric fistulas and intestinal catheters were infused intraduodenally (4·0 to 5·0 cm distal to pylorus) in association with a meal. Infusions of 0·0 ml to 15·0 ml of 3% glucose and a dye marker or 0·9% saline containing a dye marker were delivered at 1 ml/min, and stomach contents were assayed for the infusates. All three probes were detected in stomach contents. The glucose marker proved the most sensitive of the three and indicated that duodenogastric reflux occurred in a dose-dependent manner with infusions >2·5 ml.
ISSN:0195-6663
1095-8304
DOI:10.1006/appe.1996.0035