Relationship of 133Xe cerebral blood flow to middle cerebral arterial flow velocity in men at rest

Cerebral blood flow (CBF) was measured by 133Xe clearance simultaneously with the velocity of blood flow through the left middle cerebral artery (MCA) over a wide range of arterial PCO2 in eight normal men. Average arterial PCO2, which was varied by giving 4% and 6% CO2 in O2 and by controlled hyper...

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Bibliographic Details
Published in:Journal of cerebral blood flow and metabolism 1996-11, Vol.16 (6), p.1255-1262
Main Authors: Clark, J. M., Skolnick, B. E., Gelfand, R., Farber, R. E., Stierheim, M., Stevens, W. C., Beck, G. Jr, Lambertsen, C. J.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood Flow Velocity
Blood Pressure
Carbon Dioxide - physiology
Cerebral Arteries - physiology
Cerebrovascular Circulation - physiology
Humans
Investigative techniques, diagnostic techniques (general aspects)
Life Sciences (General)
Male
Medical sciences
Nervous system
Oxygen - physiology
Space life sciences
Ultrasonic investigative techniques
Xenon Radioisotopes
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Summary:Cerebral blood flow (CBF) was measured by 133Xe clearance simultaneously with the velocity of blood flow through the left middle cerebral artery (MCA) over a wide range of arterial PCO2 in eight normal men. Average arterial PCO2, which was varied by giving 4% and 6% CO2 in O2 and by controlled hyperventilation on O2, ranged from 25.3 to 49.9 mm Hg. Corresponding average values of global CBF15 were 27.2 and 65.0 ml 100 g min-1, respectively, whereas MCA blood-flow velocity ranged from 42.8 to 94.2 cm/s. The relationship of CBF to MCA blood-flow velocity over the imposed range of arterial PCO2 was described analytically by a parabola with the equation: CBF = 22.8 - 0.17 x velocity + 0.006 x velocity2 The observed data indicate that MCA blood-flow velocity is a useful index of CBF response to change in arterial PCO2 during O2 breathing at rest. With respect to baseline values measured while breathing 100% O2 spontaneously, percent changes in velocity were significantly smaller than corresponding percent changes in CBF at increased levels of arterial PCO2 and larger than CBF changes at the lower arterial PCO2. These observed relative changes are consistent with MCA vasodilation at the site of measurement during exposure to progressive hypercapnia and also during extreme hyperventilation hypocapnia.
ISSN:0271-678X
1559-7016
DOI:10.1097/00004647-199611000-00021