Effects of low pulmonary CO2 on panic anxiety

In order to investigate the possible role of hyperventilation in the pathogenesis of panic, 11 panic patients and eight normal controls underwent a hyperventilation provocation test. The word "hyperventilation" itself was not used; the subjects were told the test was meant to measure the a...

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Bibliographic Details
Published in:Comprehensive psychiatry 1988-09, Vol.29 (5), p.490-497
Main Authors: GRIEZ, E, ZANDBERGEN, J, LOUSBERG, H, VAN DEN HOUT, M
Format: Article
Language:English
Subjects:
Adult
Anxiety Disorders - blood
Anxiety Disorders - psychology
Arousal - physiology
Biological and medical sciences
Carbon Dioxide - blood
Clinical Trials as Topic
Fear - physiology
Female
Humans
Hyperventilation - blood
Hyperventilation - psychology
Lung - physiopathology
Male
Medical sciences
Methodology. Experimentation
Middle Aged
Panic - physiology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Random Allocation
Techniques and methods
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Summary:In order to investigate the possible role of hyperventilation in the pathogenesis of panic, 11 panic patients and eight normal controls underwent a hyperventilation provocation test. The word "hyperventilation" itself was not used; the subjects were told the test was meant to measure the amount of carbon dioxide in their expired air. End tidal pCO2 was reduced to less than half of its initial value, resulting in a significant increase in physical symptoms, both in patients and controls. However, there proved to be no significant increase in subjective anxiety. It is suggested, that hypocarbia alone is not sufficient to provoke anxiety in panic disorder patients.
ISSN:0010-440X
1532-8384
DOI:10.1016/0010-440X(88)90064-8