Macrophage reactions in septic arthritis

With the aid of monoclonal antibodies, macrophages can be split into functionally distinct subpopulations on the basis of their phenotype. Absence of macrophage subtypes has been noted in chronic inflammatory processes, e.g. posttraumatic osteomyelitis, rheumatoid arthritis and sarcoidosis. In the i...

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Bibliographic Details
Published in:Archives of orthopaedic and trauma surgery 1996, Vol.115 (6), p.347-350
Main Authors: PETERS, K. M, KOBERG, K, ROSENDAHL, T, KLOSTERHALFEN, B, STRAUB, A, ZWADLO-KLARWASSER, G
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Arthritis, Infectious - pathology
Bacterial arthritis and osteitis
Bacterial diseases
Biological and medical sciences
Biopsy
Child
Child, Preschool
Female
Human bacterial diseases
Humans
Infectious diseases
Macrophages - immunology
Macrophages - pathology
Male
Medical sciences
Middle Aged
Prospective Studies
Synovial Membrane - immunology
T-Lymphocytes, Regulatory - immunology
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Summary:With the aid of monoclonal antibodies, macrophages can be split into functionally distinct subpopulations on the basis of their phenotype. Absence of macrophage subtypes has been noted in chronic inflammatory processes, e.g. posttraumatic osteomyelitis, rheumatoid arthritis and sarcoidosis. In the inflammatory focus of acute septic arthritis (n = 13 patients) however, macrophages constitute the majority of immunocompetent cells. The inflammatory macrophage subtype 27E10 was clearly present in increased numbers in 11 of 13 biopsies from the inflammatory foci, showing the effector task of this subtype in synovial resistance. The anti-inflammatory macrophage subset RM3/1 was present in increased numbers in biopsies of infected tissue and the surrounding soft tissue. The occurrence of 25F9-positive macrophages, typical of the late phase of inflammation, varied widely in the biopsies.
ISSN:0936-8051
1434-3916
DOI:10.1007/BF00420330