Copper metabolism of Holstein and Jersey cows and heifers fed diets high in cupric sulfate or copper proteinate

• Published in: Journal of dairy science 1996-10, Vol.79 (10), p.1873-1880
• Main Authors: Du, Z, Hemken, R. W, Harmon, R. J
• Format: Article
• Language: English
• Subjects: actividad enzimatica; activite enzymatique; Animal productions; Animals; aspartate aminotransferase; Aspartate Aminotransferases - blood; aspartato aminotransferasa; bioavailability; biodisponibilidad; biodisponibilite; Biological and medical sciences; Biological Availability; biological differences; blood plasma; blood serum; breeds animals; Cattle - metabolism; Ceruloplasmin - metabolism; cobre; complement alimentaire; contenido de materia seca; copper; Copper - administration & dosage; Copper - blood; Copper - metabolism; Copper - pharmacokinetics; Copper Sulfate - administration & dosage; Copper Sulfate - pharmacokinetics; copper sulphate; cuivre; dairy cows; Diet; diferencias biologicas; difference biologique; dry matter content; enzymic activity; feed intake; Female; fer; ferroxidasa; ferroxidase; ferroxydase; foie; Fundamental and applied biological sciences. Psychology; genisse; heifers; hierro; higado; ingestion de piensos; iron; Iron - blood; Iron - metabolism; L-Lactate Dehydrogenase - blood; lactate dehydrogenase; lactate deshydrogenase; lactato deshidrogenasa; liver; Liver - metabolism; metabolisme des mineraux; metabolismo de minerales; mineral metabolism; mineral nutrients; novilla; nutrientes minerales; plasma sanguin; plasma sanguineo; prise alimentaire animaux; Proteins - administration & dosage; Proteins - pharmacokinetics; race animal; razas animales; serum sanguin; substance nutritive minerale; suero sanguineo; sulfate de cuivre; sulfato de cobre; suplementos; supplements; teneur en matiere seche; Terrestrial animal productions; toxicidad; toxicite; toxicity; vacas lecheras; vache laitiere; Vertebrates; Zinc - blood; Zinc - metabolism
• ISSN: 0022-0302; 1525-3198
• DOI: 10.3168/jds.S0022-0302(96)76555-4

Eight Holstein and 8 Jersey primiparous cows (3 d postcalving) and 8 Holstein and 8 Jersey growing heifers were randomly assigned to 1 of 8 treatments in a 2 X 2 X 2 factorial arrangement to compare Cu metabolism between Holsteins and Jerseys and the bioavailabilities of Cu in Cu proteinate and CuSO4. The variables were Holstein or Jersey, Cu supplementation at 5 or 80 mg/kg of DM, and supplements of CuSO4 or Cu proteinate. Jerseys had higher hepatic Cu concentrations than did Holsteins on d 60 (346 vs. 303 micrograms/g of DM). At the high Cu supplementation, hepatic Cu increased more rapidly, and content was higher in Jerseys than in Holsteins by d 60 (520 vs. 439 micrograms/g of DM). On d 0, plasma Cu concentrations were 0.99 and 0.80 micrograms/ml, and, on d 60, concentrations were 0.96 and 0.88 micrograms/ml for Jerseys and Holsteins, respectively. Overall, serum ceruloplasmin oxidase activity was greater for Jerseys than for Holsteins. Jersey cows and heifers also had greater hepatic Fe (208 vs. 173 micrograms/g of DM) and lower hepatic Zn (82 vs. 91 micrograms/g of DM) than did Holstein cows and heifers at d 60. The bioavailability of Cu in Cu proteinate and CuSO4 was the same. Plasma Cu concentration and ceruloplasmin have limited value as indicators of Cu status and availability to dairy cows and heifers.