Effect of acute induced metabolic alkalosis on the acid/base responses to sprint exercise of six racing greyhounds

• Published in: Research in veterinary science 1996-11, Vol.61 (3), p.245-251
• Main Authors: Holloway, S.A, Sundstrom, D, Senior, D.F
• Format: Article
• Language: English
• Subjects: Acid-Base Equilibrium - drug effects; Administration, Oral; Alkalosis; Animals; Blood Proteins - metabolism; Carbon Dioxide - blood; Dogs; Electrolytes - blood; Hydrogen-Ion Concentration; Lactates - blood; Oxygen - blood; Partial Pressure; Physical Conditioning, Animal; Physical Exertion; Sodium Bicarbonate - administration & dosage; Sodium Bicarbonate - pharmacology; Time Factors
• ISSN: 0034-5288; 1532-2661
• DOI: 10.1016/S0034-5288(96)90072-7

To investigate the effect of acute induced metabolic alkalosis on the haematological, biochemical and metabolic responses to sprint exercise, six greyhound dogs with previously placed carotid artetrial catheters were raced four times over a distance of 400 metres. Each dog was raced twice after receiving oral sodium bicarbonate solution (NaHCO 3) (400 mg kg −1) or lactated Ringer's solution ( LRS). Before, and for intervals of up to one hour after, the exercise arterial blood samples were collected for the measurement of blood gases, packed cell volume, total protein, serum biochemistry and plasma lactate. The time to complete the 400 metre sprint ranged from 32·7 seconds to 36·9 seconds. There was no significant difference in racing times between the dogs treated with NaHCO 3 and LRS, and there was no significant difference between the plasma lactate measurements after the treatments with NaHCO 3 or LRS. Serum chloride concentrations were significantly lower after NaHCO 3 than after LRS, and there was a trend towards a lower serum potassium concentration after NaHCO 3 treatment. Plasma lactate concentrations showed a similar increase and time course of disappearance after both LRS and NaHCO 3 treatments. There were significant changes in all the parameters measured after the exercise, but there were large variations between individual dogs and between races when the dogs were receiving the same treatment.