Changes in splenic volume after partial splenic embolization in children

• Published in: Journal of pediatric surgery 1996-02, Vol.31 (2), p.241-244
• Main Authors: Watanabe, Yasuhiro, Todani, Takuji, Noda, Takuo
• Format: Article
• Language: English
• Subjects: Adolescent; Biological and medical sciences; Child; Embolization, Therapeutic; Female; Humans; Hypersplenism - complications; Hypersplenism - therapy; Infant; Liver, biliary tract, pancreas, portal circulation, spleen; Male; Medical sciences; Spleen - diagnostic imaging; Spleen - physiology; Splenomegaly - etiology; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; Thrombocytopenia - etiology; Tomography, X-Ray Computed
• ISSN: 0022-3468; 1531-5037
• DOI: 10.1016/S0022-3468(96)90006-8

Aim: The authors studied changes in splenic volume after partial splenic embolization (PSE) in children who had thrombocytopenia caused by splenomegaly. Materials and Methods: Five children with hypersplenism (ages of 1, 6, 7, 10, and 14 years) underwent PSE. The follow-up period ranged from 1 month to 8 years 9 months. Whole and infarcted splenic volumes were measured from computed tomography images obtained before and after PSE. Results: Within 2 weeks after PSE, the whole splenic volume increased to 110% to 140% of the pre-PSE volume. The infacted area disappeared 3 to 4 months after PSE, and the whole splenic volume decreased markedly. The decreased volume tended to be stable during the follow-up period. The splenic enlargement before PSE ranged from 7.2 to 14.2 times the standard splenic volume for a corresponding body weight. The splenic volume did not become normal after PSE; it remained between 2 and 7 times larger than standard. Platelet counts stayed above 10 × 10 4/mm 3 when the splenic volume reduced to 2 times the standard volume. Conclusion: The first 4 weeks after PSE is the most dangerous period for the development of splenic rupture because of marked expansion of the splenic capsule. The infarcted parenchyma is absorbed 3 to 4 months after PSE, and the whole splenic volume is reduced. Thereafter, the splenic volume is stable for several years. Reembolization is not likely to be necessary in the majority of patients who have had splenic embolization with an infarction rate of ≥80%.