Plasma dopamine and norepinephrine correlations with psychomotor retardation, anxiety, and depression in non-psychotic depressed patients: a pilot study

The relationship of plasma catecholamine levels to severity of depression and psychomotor retardation was examined in 12 male inpatients who met criteria for major depressive episode. Psychomotor retardation was measured with the Psychomotor Retardation Rating Scale (PRRS), and depression was assess...

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Bibliographic Details
Published in:Psychiatry research 1996-10, Vol.64 (3), p.209-211
Main Authors: Hamner, Mark B., Diamond, Bruce I.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Affective disorder
Aged
Anxiety Disorders - blood
Anxiety Disorders - diagnosis
Anxiety Disorders - psychology
Biological and medical sciences
Blood pressure
Catecholamines
Depression
Depressive Disorder - blood
Depressive Disorder - diagnosis
Depressive Disorder - psychology
Dopamine - blood
Humans
Male
Medical sciences
Middle Aged
Mood disorders
Norepinephrine - blood
Personality Inventory
Pilot Projects
Post-traumatic stress disorder
Psychology. Psychoanalysis. Psychiatry
Psychomotor Disorders - blood
Psychomotor Disorders - diagnosis
Psychomotor Disorders - psychology
Psychopathology. Psychiatry
Reaction Time - physiology
Veterans - psychology
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Summary:The relationship of plasma catecholamine levels to severity of depression and psychomotor retardation was examined in 12 male inpatients who met criteria for major depressive episode. Psychomotor retardation was measured with the Psychomotor Retardation Rating Scale (PRRS), and depression was assessed with the Hamilton Rating Scale for Depression (HRSD). Blood samples for biochemical measurements were obtained from drug-free patients at approximately 09:00 h. Plasma dopamine (DA) levels correlated significantly with the HRSD total score and the anxiety subscale score. Plasma norepinephrine (NE) levels demonstrated a trend toward a negative correlation with the HRSD total score. Neither plasma DA nor NE levels showed a significant correlation with either the global PRRS score or the cognitive or motor subscale score. HRSD scores failed to correlate with the PRRS scores.
ISSN:0165-1781
1872-7123
DOI:10.1016/S0165-1781(96)02879-X