The utility of non-β-lactam antimicrobial MICs as markers to distinguish oxacillin-resistant from oxacillin-susceptible strains of Staphylococcus epidermidis

Among 6,068 strains of Staphylococcus epidermidis, 75.5% were oxacillin-resistant. Oxacillin-susceptible strains were more frequently susceptible to erythromycin, clindamycin, ciprofloxacin, trimethoprim/sulfamethoxazole, gentamicin, and tetracycline than oxacillin-resistant strains. With the except...

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Bibliographic Details
Published in:Diagnostic microbiology and infectious disease 1996-09, Vol.26 (1), p.43-45
Main Authors: Fass, Robert J., Barnishan, Jean, Ayers, Leona W.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Biomarkers
Ciprofloxacin - pharmacology
Clindamycin - pharmacology
Drug Resistance, Microbial
Erythromycin - pharmacology
Gentamicins - pharmacology
Medical sciences
Microbial Sensitivity Tests
Oxacillin - pharmacology
Penicillins - pharmacology
Pharmacology. Drug treatments
Staphylococcus epidermidis - drug effects
Tetracycline - pharmacology
Trimethoprim, Sulfamethoxazole Drug Combination - pharmacology
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Summary:Among 6,068 strains of Staphylococcus epidermidis, 75.5% were oxacillin-resistant. Oxacillin-susceptible strains were more frequently susceptible to erythromycin, clindamycin, ciprofloxacin, trimethoprim/sulfamethoxazole, gentamicin, and tetracycline than oxacillin-resistant strains. With the exception of erythromycin, non-β-lactam MICs were less discriminatory for identifying oxacillin-resistant strains with oxacillin MICs ⩽2 μg/ml than for those with oxacillin MICs ⩾4 μg/ml.
ISSN:0732-8893
1879-0070
DOI:10.1016/S0732-8893(96)00163-0