PARKINSONISM AND THE ANAESTHETIST

There are similarities between the motor disorder of Parkinsonism, the rigidity associated with the use of opioid drugs and the phenomenon of shaking during recovery from anaesthesia. Opioid receptors of the basal ganglia modulate activity of dopaminergic neurones. Opioid induced rigidity, therefore...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1988-12, Vol.61 (6), p.761-770
Main Author: SEVERN, A.M.
Format: Article
Language:English
Subjects:
Anesthesia
Anesthesia - adverse effects
Anesthesia depending on patient's condition
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Biological and medical sciences
Humans
Medical sciences
Parkinson Disease
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Description
Summary:There are similarities between the motor disorder of Parkinsonism, the rigidity associated with the use of opioid drugs and the phenomenon of shaking during recovery from anaesthesia. Opioid receptors of the basal ganglia modulate activity of dopaminergic neurones. Opioid induced rigidity, therefore, may be a form of drug-induced Parkinsonism. This has implications for the anaesthetic management of the patient with Parkinsonism. Previous descriptions of the anaesthetic management of Parkinsonism have emphasized the cardiovascular complications of L-Dopa therapy, but have not discussed the importance of opioids.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/61.6.761