Low-Wavenumber Raman and Synchrotron Studies of Proteins and Protein/Water Interactions. From Model System to Animal and Human Skin

Water is the most abundant substance in human cells. Water accounts for about 70% of a cell's weight. Water is important for protein dynamics and function in living cells. However, the role of water in bio-systems is far from well understood. In this context hydrogen bonding is certainly an imp...

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Bibliographic Details
Main Authors: Nielsen, O F, Greve, T M, De Fries, N, Larsen, N W, Engdahl, A
Format: Conference Proceeding
Language:English
Subjects:
Animals
Band spectra
Bands
Bonding
Dynamical systems
Dynamics
Hides
Human
Hydrogen bonding
Hydrogen bonds
Mathematical models
Proteins
Spectroscopy
Stretching
Synchrotrons
Wavenumber
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Summary:Water is the most abundant substance in human cells. Water accounts for about 70% of a cell's weight. Water is important for protein dynamics and function in living cells. However, the role of water in bio-systems is far from well understood. In this context hydrogen bonding is certainly an important aspect. Vibrational spectroscopy is an important tool in studies of bio-molecular hydrogen bonding. For this purpose the NH and OH-stretching regions are most often used, but the stretching bands are only slightly perturbed by changes in the hydrogen bonds. The low wavenumber spectrum from around 50 to 300 cm yields more direct information about the hydrogen bonds1. In a Raman spectrum the Rayleigh line may extend to several hundred wavenumbers and hide the Raman bands. This problem is overcome by use of the R((v)-representation, Eq.1.
ISSN:0094-243X
DOI:10.1063/1.3482561