Bioavailability study of paracetamol tablets in saliva and urine

A bioavailability study of two lots of paracetamol tablets was carried out in 5 healthy volunteers, using a crossover aleatory design, and drug monitoring in urine and saliva by high performance liquid chromatography (HPLC). Results were correlated with those obtained in an in vitro dissolution stud...

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Bibliographic Details
Published in:European journal of drug metabolism and pharmacokinetics 1996-10, Vol.21 (4), p.295-300
Main Authors: RETACO, P, GONZALEZ, M, PIZZORNO, M. T, VOLONTE, M. G
Format: Article
Language:English
Subjects:
Acetaminophen - analysis
Acetaminophen - pharmacokinetics
Acetaminophen - urine
Adult
Analgesics
Analgesics, Non-Narcotic - chemistry
Analgesics, Non-Narcotic - pharmacokinetics
Analgesics, Non-Narcotic - urine
Biological and medical sciences
Biological Availability
Female
Humans
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Saliva - chemistry
Tablets
Therapeutic Equivalency
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Summary:A bioavailability study of two lots of paracetamol tablets was carried out in 5 healthy volunteers, using a crossover aleatory design, and drug monitoring in urine and saliva by high performance liquid chromatography (HPLC). Results were correlated with those obtained in an in vitro dissolution study. Statistical evaluation of bioavailability parameters indicates that the two formulations may be considered bioequivalent, in spite of differences found during early stages of the absorption process, which were preventable according to an in vitro dissolution study.
ISSN:0378-7966
2107-0180
DOI:10.1007/BF03189730