cdc2 links the Drosophila cell cycle and asymmetric division machineries

Asymmetric cell divisions can be mediated by the preferential segregation of cell-fate determinants into one of two sibling daughters. In Drosophila neural progenitors, Inscuteable, Partner of Inscuteable and Bazooka localize as an apical cortical complex at interphase, which directs the apical-basa...

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Published in:Nature (London) 2001-02, Vol.409 (6823), p.1063-1067
Main Authors: Chia, William, Tio, Murni, Udolph, Gerald, Yang, Xiaohang
Format: Article
Language:English
Subjects:
Animals
Asymmetry
Biological and medical sciences
Carrier Proteins - physiology
Cdc2 protein
CDC2 Protein Kinase - genetics
CDC2 Protein Kinase - physiology
Cell Cycle
Cell Cycle Proteins - physiology
Cell Division
Cells
Central Nervous System - cytology
Cyclins - metabolism
Cytoskeletal Proteins - physiology
Determinants
Division
Drosophila
Drosophila Proteins
Embryology: invertebrates and vertebrates. Teratology
Embryos
Fundamental and applied biological sciences. Psychology
Genotype
Humanities and Social Sciences
Insects
letter
Links
Localization
Mitosis
multidisciplinary
Mutation
Nerve Tissue Proteins - physiology
Nervous system
Neuropeptides
Nuclear Proteins - physiology
Organogenesis. Fetal development
Organogenesis. Physiological fonctions
Phenotype
Phosphorylation
Position (location)
Proteins
Science
Science (multidisciplinary)
Transcription Factors
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description Asymmetric cell divisions can be mediated by the preferential segregation of cell-fate determinants into one of two sibling daughters. In Drosophila neural progenitors, Inscuteable, Partner of Inscuteable and Bazooka localize as an apical cortical complex at interphase, which directs the apical-basal orientation of the mitotic spindle as well as the basal/cortical localization of the cell-fate determinants Numb and/or Prospero during mitosis. Although localization of these proteins shows dependence on the cell cycle, the involvement of cell-cycle components in asymmetric divisions has not been demonstrated. Here we show that neural progenitor asymmetric divisions require the cell-cycle regulator cdc2. By attenuating Drosophila cdc2 function without blocking mitosis, normally asymmetric progenitor divisions become defective, failing to correctly localize asymmetric components during mitosis and/or to resolve distinct sibling fates. cdc2 is not necessary for initiating apical complex formation during interphase; however, maintaining the asymmetric localization of the apical components during mitosis requires Cdc2/B-type cyclin complexes. Our findings link cdc2 with asymmetric divisions, and explain why the asymmetric localization of molecules like Inscuteable show cell-cycle dependence.
doi_str_mv 10.1038/35059124
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In Drosophila neural progenitors, Inscuteable, Partner of Inscuteable and Bazooka localize as an apical cortical complex at interphase, which directs the apical-basal orientation of the mitotic spindle as well as the basal/cortical localization of the cell-fate determinants Numb and/or Prospero during mitosis. Although localization of these proteins shows dependence on the cell cycle, the involvement of cell-cycle components in asymmetric divisions has not been demonstrated. Here we show that neural progenitor asymmetric divisions require the cell-cycle regulator cdc2. By attenuating Drosophila cdc2 function without blocking mitosis, normally asymmetric progenitor divisions become defective, failing to correctly localize asymmetric components during mitosis and/or to resolve distinct sibling fates. cdc2 is not necessary for initiating apical complex formation during interphase; however, maintaining the asymmetric localization of the apical components during mitosis requires Cdc2/B-type cyclin complexes. 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subjects Animals
Asymmetry
Biological and medical sciences
Carrier Proteins - physiology
Cdc2 protein
CDC2 Protein Kinase - genetics
CDC2 Protein Kinase - physiology
Cell Cycle
Cell Cycle Proteins - physiology
Cell Division
Cells
Central Nervous System - cytology
Cyclins - metabolism
Cytoskeletal Proteins - physiology
Determinants
Division
Drosophila
Drosophila Proteins
Embryology: invertebrates and vertebrates. Teratology
Embryos
Fundamental and applied biological sciences. Psychology
Genotype
Humanities and Social Sciences
Insects
letter
Links
Localization
Mitosis
multidisciplinary
Mutation
Nerve Tissue Proteins - physiology
Nervous system
Neuropeptides
Nuclear Proteins - physiology
Organogenesis. Fetal development
Organogenesis. Physiological fonctions
Phenotype
Phosphorylation
Position (location)
Proteins
Science
Science (multidisciplinary)
Transcription Factors
title cdc2 links the Drosophila cell cycle and asymmetric division machineries
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