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The swinging lever-arm hypothesis of muscle contraction
The molecular mechanism of muscle contraction is a problem that has exercised biophysicists and biochemists for many years. The common view of the mechanism is embodied in the ‘cross-bridge hypothesis’, in which the relative sliding of thick (myosin) and thin (actin) filaments in cross-striated musc...
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| Published in: | Current Biology 1997-02, Vol.7 (2), p.R112-R118 |
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| Format: | Article |
| Language: | English |
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| container_start_page | R112 |
| container_title | Current Biology |
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| creator | Holmes, Kenneth C |
| description | The molecular mechanism of muscle contraction is a problem that has exercised biophysicists and biochemists for many years. The common view of the mechanism is embodied in the ‘cross-bridge hypothesis’, in which the relative sliding of thick (myosin) and thin (actin) filaments in cross-striated muscle is brought about by the ‘cross-bridges’, parts of the myosin molecules which protrude from the thick filaments and interact cyclically with the actin filaments, transporting them by a rowing action that is powered by the hydrolysis of ATP. This hypothesis is, however, rather vague on the molecular details of cross-bridge movement and, in the light of the recently determined crystal structures of myosin and actin, it has evolved into the more precise ‘swinging lever-arm hypothesis’. |
| doi_str_mv | 10.1016/S0960-9822(06)00051-0 |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 0960-9822 |
| ispartof | Current Biology, 1997-02, Vol.7 (2), p.R112-R118 |
| issn | 0960-9822 1879-0445 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78802538 |
| source | BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS |
| subjects | Actins - chemistry Actins - metabolism Adenosine Diphosphate - metabolism Adenosine Triphosphate - metabolism Animals Dictyostelium - physiology Models, Biological Models, Molecular Models, Structural Muscle Contraction Muscle, Skeletal - physiology Muscle, Skeletal - ultrastructure Myosins - chemistry Myosins - metabolism Protein Structure, Secondary Vanadates - metabolism |
| title | The swinging lever-arm hypothesis of muscle contraction |
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