Rationale for active vitamin D analog therapy in senile osteoporosis

PTH is a potent endogenous stimulator of bone resorption, and PTH secretion increases with age (i.e., secondary hyperparathyroidism). Accordingly, secondary hyperparathyroidism may contribute to the pathogenesis of senile osteoporosis. We postulate that there is a subgroup of elderly subjects who ha...

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Bibliographic Details
Published in:Calcified tissue international 1997-01, Vol.60 (1), p.100-105
Main Authors: Akesson, K, Lau, K H, Baylink, D J
Format: Article
Language:English
Subjects:
Aged
Aging
Calcitriol - therapeutic use
Female
Humans
Osteoporosis - drug therapy
Osteoporosis - physiopathology
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Summary:PTH is a potent endogenous stimulator of bone resorption, and PTH secretion increases with age (i.e., secondary hyperparathyroidism). Accordingly, secondary hyperparathyroidism may contribute to the pathogenesis of senile osteoporosis. We postulate that there is a subgroup of elderly subjects who have elevated serum PTH because of 1,25(OH)^sub 2^D^sub 3^ deficiency/resistance or both. We believe that with appropriate vitamin D therapy (vitamin D, 1,25(OH)^sub 2^D^sub 3^ or 1α(OH)D^sub 3^) and adequate calcium, much of the problem associated with secondary hyperparathyroidism seen in the senile osteoporotic patient can be effectively treated.[PUBLICATION ABSTRACT]
ISSN:0171-967X
1432-0827
DOI:10.1007/s002239900195