Intensity and frequency functions of [ 14C]2-deoxyglucose labelling in the central nucleus of the inferior colliculus in the cat

The frequency organization of the central nucleus of the inferior colliculus (ICC) in the anesthetised cat was quantitatively mapped using [ 14C]2-deoxyglucose. From a standardised rostrocaudal region of the ICC, the position of peak selective labelling along the tonotopic axis closely conformed to...

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Bibliographic Details
Published in:Hearing research 1997-02, Vol.104 (1), p.73-89
Main Authors: Brown, Mel, Webster, William R., Martin, Russell L.
Format: Article
Language:English
Subjects:
Acoustic Stimulation
Animals
Autoradiography
Carbon Radioisotopes
Cats
Deoxyglucose - metabolism
Frequency selectivity
Image Processing, Computer-Assisted
Inferior Colliculi - cytology
Inferior Colliculi - metabolism
Inferior Colliculi - physiology
Isotope Labeling
Olivary Nucleus - cytology
Olivary Nucleus - metabolism
Olivary Nucleus - physiology
Tonotopic
Ventromedial Hypothalamic Nucleus - cytology
Ventromedial Hypothalamic Nucleus - metabolism
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Summary:The frequency organization of the central nucleus of the inferior colliculus (ICC) in the anesthetised cat was quantitatively mapped using [ 14C]2-deoxyglucose. From a standardised rostrocaudal region of the ICC, the position of peak selective labelling along the tonotopic axis closely conformed to the reported tonotopic organization of this nucleus. The position of the peak was found not to significantly change its position along the tonotopic axis with increasing stimulus intensity. However, the amplitude of peak uptake and width of selective labelling were shown to monotonically increase with increase in stimulus intensity. The increase in width of selective labelling, about the position of peak uptake, showed a slight asymmetry toward the high-frequency regions of the ICC. A 2-DG frequency-position function for the ICC, similar to that for the cochlea, enabled the width of 2-DG bands to be expressed in terms of their frequency spread along the tonotopic axis. This inturn enabled 2-DG tuning curves to be plotted which, when compared to electrophysiologically determined tuning curves, showed marked similarities. The minimum threshold and width ( Q 10) of these 2-DG tuning curves fell within the range reported for single units in the cat auditory pathway.
ISSN:0378-5955
1878-5891
DOI:10.1016/S0378-5955(96)00186-4