Comparative efficacy of inhaled furosemide and disodium cromoglycate in the treatment of exercise-induced asthma in children

Background: Inhaled furosemide has been shown, in patients with asthma, to have prophylactic properties similar to those of disodium cromoglycate. Objective: The aim of this study was to evaluate the protective effect of these drugs in the treatment of exercise-induced asthma. Methods: Fifteen child...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 1997-02, Vol.99 (2), p.204-209
Main Authors: Melo, Raul E., Solé, Dirceu, Naspitz, Charles K.
Format: Article
Language:English
Subjects:
Administration, Inhalation
Adolescent
Anti-Asthmatic Agents - administration & dosage
Anti-Asthmatic Agents - therapeutic use
Asthma, Exercise-Induced - drug therapy
Biological and medical sciences
Child
children
Cromolyn Sodium - administration & dosage
Cromolyn Sodium - therapeutic use
Cross-Over Studies
disodium cromoglycate
Diuretics - administration & dosage
Diuretics - therapeutic use
Exercise Test
Exercise-induced asthma
Female
Furosemide - administration & dosage
Furosemide - therapeutic use
Humans
inhaled furosemide
Male
Medical sciences
Pharmacology. Drug treatments
Respiratory system
Single-Blind Method
Spirometry
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Summary:Background: Inhaled furosemide has been shown, in patients with asthma, to have prophylactic properties similar to those of disodium cromoglycate. Objective: The aim of this study was to evaluate the protective effect of these drugs in the treatment of exercise-induced asthma. Methods: Fifteen children with exercise-induced asthma (mean age, 10.8 years) underwent exercise challenge after a single dose of nebulized placebo, furosemide (20 mg/m 2 body area), or disodium cromoglycate (20 mg), 2 days apart, in a single-blind crossover trial. Results: Both furosemide and disodium cromoglycate exerted significant protection against the bronchial response to exercise challenge, with a mean maximum percentage falls in FEV 1 of 4.66% and 7.22%, respectively ( p < 0.05). On the placebo day, the mean maximum percentage fall in FEV 1 was 34.50% ( p< 0.05). Conclusion: The results of this study suggest that furosemide and disodium cromoglycate provide comparable efficacy in preventing exercise-induced asthma in children, with no side effects. (J Allergy Clin Immunol 1997;99:204-9.)
ISSN:0091-6749
1097-6825
DOI:10.1016/S0091-6749(97)70097-6