Effects of long-term training on the progression of chronic renal failure in rats

To evaluate the effects of long-term exercise on the progression of chronic renal failure (CRF), adult Munich-Wistar rats with 5/6 renal mass ablation were submitted to treadmill exercise for 30 min 5 times/wk for 60 d. Whole kidney function and glomerular hemodynamics, proteinuria, and glomerular s...

Full description

Saved in:
Bibliographic Details
Published in:Medicine and science in sports and exercise 1997-02, Vol.29 (2), p.169-174
Main Authors: BERGAMASCHI, C. T, BOIM, M. A, MOURA, L. A, PICARRO, I. C, SCHOR, N
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Disease Models, Animal
Disease Progression
Glomerular Filtration Rate
Hemodynamics
Kidney Failure, Chronic - physiopathology
Kidney Glomerulus - physiopathology
Male
Medical sciences
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Oxygen Consumption
Physical Conditioning, Animal - physiology
Proteinuria
Rats
Renal failure
Sclerosis
Space life sciences
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To evaluate the effects of long-term exercise on the progression of chronic renal failure (CRF), adult Munich-Wistar rats with 5/6 renal mass ablation were submitted to treadmill exercise for 30 min 5 times/wk for 60 d. Whole kidney function and glomerular hemodynamics, proteinuria, and glomerular sclerosis were evaluated in 4 groups: Control, Sham trained (Sham + Ex), rats submitted to 5/6 nephrectomy (CRF) and maintained sedentary, and rats with 5/6 nephrectomy and trained (CRF + Ex). The groups with chronic renal failure (sedentary and trained) presented a reduction in total glomerular filtration rate (GFR) and in renal plasma flow (RPF), accompanied by an increase in single nephron GFR (SNGFR) and glomerular plasma flow (QA). However, the CRF + EX group did not show the glomerular hypertension observed in the CRF group. Despite the normalization of glomerular hypertension, proteinuria and sclerosis index were not different from the CRF sedentary group. Physical training provoked a vasodilatation of efferent arterioles, which induced the normalization of glomerular hypertension. These results suggest that the reduction alone of glomerular hypertension induced by exercise does not prevent the progression of renal disease, indicating the participation of other associated factors in this experimental model.
ISSN:0195-9131
1530-0315
DOI:10.1097/00005768-199702000-00001