Effects of Indobufen and Pentoxifylline on Walking Capacity and Hemostasis in Patients with Intermittent Claudication: Results of Six Months of Treatment

Seventy-one patients with peripheral arterial occlusive disease (PAOD) were random ized into two groups of different treatment modalities. The diagnosis of PAOD was estab lished by history of intermittent claudication, clinical examination, and by Doppler pressure assessment or lower extremity arter...

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Bibliographic Details
Published in:Angiology 1997-03, Vol.48 (3), p.247-254
Main Authors: Panchenko, E., Eshkeeva, A., Dobrovolsky, A., Titaeva, E., Podinovskaya, Ya, Hussain, K.M.A., Karpov, Yu, Panchenko, Elizaveta
Format: Article
Language:English
Subjects:
beta-Thromboglobulin - analysis
Fibrinogen - analysis
Hemostasis - drug effects
Humans
Intermittent Claudication - drug therapy
Isoindoles
Middle Aged
Pentoxifylline - therapeutic use
Phenylbutyrates - therapeutic use
Platelet Aggregation Inhibitors - therapeutic use
Treatment Outcome
Vasodilator Agents - therapeutic use
Walking - physiology
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Summary:Seventy-one patients with peripheral arterial occlusive disease (PAOD) were random ized into two groups of different treatment modalities. The diagnosis of PAOD was estab lished by history of intermittent claudication, clinical examination, and by Doppler pressure assessment or lower extremity arteriography. After a three-month washout period, 35 patients (Group 1) started treatment with indobufen (400 mg per day) and 36 patients (Group 2) with pentoxifylline (600 mg per day). Twenty-nine patients from each group completed six months of treatment. Both of the drugs significantly improved maximal and pain-free walking distances, but the effect of indobufen was more pronounced than that of pentoxifylline. Patients with PAOD exhibited signs of hyperco agulation. Fibrinogen, D-dimer, and b-thromboglobulin concentrations did not change significantly following treatment in both of the groups. The authors observed a decrease of platelet aggregation after treatment with indobufen and a decrease of F1+2 fragment and PAI-1 antigen after treatment with pentoxifylline.
ISSN:0003-3197
1940-1574
DOI:10.1177/000331979704800308