Oxidized Low Density Lipoproteins Impair Peripheral Blood Mononuclear Cell Proliferation and Cytokine Production

Oxidized low density lipoproteins (ox-LDL) are known to behave as physiological pro-oxidants leading to the formation of intracellular reactive oxygen species. The presence of these altered lipoproteins in the human plasma has been associated with a number of morbid states, including atherosclerosis...

Full description

Saved in:
Bibliographic Details
Published in:Biochemical and biophysical research communications 1997-03, Vol.232 (2), p.359-363
Main Authors: Viora, Marina, Straface, Elisabetta, Genova, Gianfranco Di, Fattorossi, Andrea, Rivabene, Roberto, Camponeschi, Barbara, Masella, Roberta, Malorni, Walter
Format: Article
Language:English
Subjects:
Cell Division - drug effects
Cytokines - biosynthesis
Cytokines - drug effects
Cytokines - genetics
Cytokines - metabolism
Humans
Interleukin-2 - pharmacology
Leukocytes, Mononuclear - cytology
Leukocytes, Mononuclear - drug effects
Leukocytes, Mononuclear - metabolism
Lipoproteins, LDL - pharmacology
Mitogens - pharmacology
Oxidation-Reduction
RNA, Messenger - biosynthesis
Tuberculin - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Oxidized low density lipoproteins (ox-LDL) are known to behave as physiological pro-oxidants leading to the formation of intracellular reactive oxygen species. The presence of these altered lipoproteins in the human plasma has been associated with a number of morbid states, including atherosclerosis and immunodeficiency. Common features of such pathological conditions seem to be represented by several alterations occurring in the immune system. In this work we analyze thein vitroeffects of ox-LDL on both proliferative response and cytokine production of normal human peripheral blood mononuclear cells (PBMC). Our results indicate that ox-LDL significantly inhibit proliferative response and modulate cytokine network interfering both at protein secretion and mRNA synthesis level.
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.1997.6294