Analysis of 281,797 Consecutive Blood Cultures Performed over an Eight-Year Period: Trends in Microorganisms Isolated and the Value of Anaerobic Culture of Blood

The results for 281,797 blood culture sets of specimens collected from adult patients at the Mayo Clinic over an approximately 8-year period (1 November 1984 through 30 November 1992) were analyzed in order to determine whether there were differences in the types of microorganisms isolated over this...

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Bibliographic Details
Published in:Clinical infectious diseases 1997-03, Vol.24 (3), p.403-418
Main Authors: Cockerill, Franklin R., Hughes, John G., Vetter, Emily A., Mueller, Roger A., Weaver, Amy L., Ilstrup, Duane M., Rosenblatt, Jon E., Wilson, Walter R.
Format: Article
Language:English
Subjects:
Adult
Anaerobic bacteria
Anaerobiosis
Bacteremia
Bacteremia - diagnosis
Bacteria, Aerobic - isolation & purification
Bacteria, Anaerobic - isolation & purification
Bacteriological Techniques
Biological and medical sciences
Blood
Blood - microbiology
Bottles
Clinical Articles
Clostridium
Colony Count, Microbial
Cultural groups
Culture Media
Fungi - isolation & purification
General aspects
Human infectious diseases. Experimental studies and models
Humans
Infections
Infectious diseases
Medical sciences
Pathogens
Staphylococcus
Streptococcus
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Summary:The results for 281,797 blood culture sets of specimens collected from adult patients at the Mayo Clinic over an approximately 8-year period (1 November 1984 through 30 November 1992) were analyzed in order to determine whether there were differences in the types of microorganisms isolated over this time and to assess the usefulness of anaerobic culturing of blood. Each blood culture set consisted of two aerobic blood cultures (Septi-Chek [Becton Dickinson, Sparks, MD] and Isolator [Wampole Laboratories, Cranbury, NJ]) and one anaerobic culture (nonvented tryptic or trypticase soy broth [NVTSB; Difco Laboratories, Detroit, or Becton Dickinson]). The relative frequency of isolation of aerobic and facultatively anaerobic gram-positive bacteria and obligately anaerobic bacteria increased over the second half of the 1984–1992 surveillance period. The value of the NVTSB anaerobic blood culture was demonstrated for diagnosing bloodstream infections caused by certain facultatively anaerobic bacteria in addition to obligately anaerobic bacteria and supported the inclusion of the NVTSB anaerobic blood culture as a standard part of the three-component blood culture set used at this institution.
ISSN:1058-4838
1537-6591
DOI:10.1093/clinids/24.3.403