Attenuation of electroconvulsive therapy induced hypertension with sublingual nifedipine

Five patients known to be previously hypertensive but not currently receiving anti-hypertensive medications were studied for a total of twenty-six administrations of electroconvulsive therapy. Patients randomly received sublingual nifedipine 10 mg, 20 minutes prior to half of their treatments, and f...

Full description

Saved in:
Bibliographic Details
Published in:Anaesthesia and intensive care 1989-02, Vol.17 (1), p.31-33
Main Authors: WELLS, D. G, DAVIES, G. G, ROSEWARNE, F
Format: Article
Language:English
Subjects:
Administration, Sublingual
Aged
Antihypertensive agents
Biological and medical sciences
Blood Pressure - drug effects
Cardiovascular system
Depressive Disorder - therapy
Drug Evaluation
Electroconvulsive Therapy - adverse effects
Female
Humans
Hypertension - etiology
Hypertension - prevention & control
Male
Medical sciences
Middle Aged
Nifedipine - administration & dosage
Nifedipine - pharmacology
Nifedipine - therapeutic use
Pharmacology. Drug treatments
Random Allocation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Five patients known to be previously hypertensive but not currently receiving anti-hypertensive medications were studied for a total of twenty-six administrations of electroconvulsive therapy. Patients randomly received sublingual nifedipine 10 mg, 20 minutes prior to half of their treatments, and for the remaining treatments acted as their own controls. The use of nifedipine resulted in significant attenuation of the blood pressure response to therapy. Systolic pressure increase was 24 mmHg (SD 14) versus 62 mmHg (SD 24) (P less than 0.01). There was no difference in heart rate between the two groups. It is concluded that nifedipine reduces the pressor response to electroconvulsive therapy in individuals with a history of hypertension.
ISSN:0310-057X
1448-0271
DOI:10.1177/0310057x8901700107