Cellular immune reactions directed against Toxoplasma gondii with special emphasis on the central nervous system

Toxoplasma gondii is an obligate intracellular parasite which, after primary infection of humans, is maintained in a dormant state by the host cellular immune system. In the event of an acquired immunosuppression, those parasites surviving as dormant cysts in the host may undergo a change in status,...

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Bibliographic Details
Published in:Medical microbiology and immunology 1997-03, Vol.185 (4), p.195-206
Main Authors: DÄUBENER, W, HADDING, U
Format: Article
Language:English
Subjects:
Astrocytes - immunology
Astrocytes - parasitology
Biological and medical sciences
Brain - cytology
Brain - immunology
Brain - parasitology
Cytokines - immunology
Fundamental and applied biological sciences. Psychology
Human protozoal diseases
Humans
Immunity, Cellular
Infectious diseases
Life cycle. Host-agent relationship. Pathogenesis
Medical sciences
Microglia - immunology
Microglia - parasitology
Neuroglia - immunology
Neuroglia - parasitology
Nitric Oxide
Parasitic diseases
Protozoa
Protozoal diseases
Respiratory Burst
T-Lymphocytes - immunology
Toxoplasmosis
Toxoplasmosis, Cerebral - immunology
Tryptophan - metabolism
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Summary:Toxoplasma gondii is an obligate intracellular parasite which, after primary infection of humans, is maintained in a dormant state by the host cellular immune system. In the event of an acquired immunosuppression, those parasites surviving as dormant cysts in the host may undergo a change in status, proliferate and cause a life-threatening toxoplasmic encephalitis. Over the last decade much knowledge has accumulated concerning the immune response against T. gondii. This review focuses attention particularly on the anti-parasitic effector mechanisms and the cellular immune reactions in the central nervous system during the course of reactivated toxoplasmic encephalitis.
ISSN:0300-8584
1432-1831
DOI:10.1007/s004300050031