Conventional and quantitative liver function tests after hepatic transplantation : a prospective long term follow-up

In long-term survivors of liver transplantation, hepatic function is obviously of vital importance. Therefore, we prospectively performed conventional and quantitative liver function tests in patients who had survived a first transplantation for at least 4 years. Compared to 6 months after transplan...

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Bibliographic Details
Published in:Transplant international 1997-05, Vol.10 (3), p.212-216
Main Authors: SCHÖNFELD, J. V, ERHARD, J, BESTE, M, MAHL, M, ZOTZ, R. B, LANGE, R, BREUER, N, GOEBELL, H, EIGLER, F. W
Format: Article
Language:English
Subjects:
Adult
Bilirubin - blood
Biological and medical sciences
Humans
Lidocaine - analogs & derivatives
Lidocaine - metabolism
Liver - metabolism
Liver Function Tests
Liver Transplantation - physiology
Liver, biliary tract, pancreas, portal circulation, spleen
Medical sciences
Metabolic Clearance Rate
Middle Aged
Prospective Studies
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
Time Factors
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Summary:In long-term survivors of liver transplantation, hepatic function is obviously of vital importance. Therefore, we prospectively performed conventional and quantitative liver function tests in patients who had survived a first transplantation for at least 4 years. Compared to 6 months after transplantation, serum bilirubin concentration and gamma GT activity were significantly lower after 3, 4, and 5 years (bilirubin 1.2 +/- 0.2 mg/dl at 6 months vs 1.0 +/- 0.1, 1.0 +/- 0.2, and 0.8 +/- 0.1 mg/dl respectively; gamma GT 106 +/- 0 33 U/l at 6 months vs 56 +/- 17, 67 +/- 35, 39 +/- 10 U/l respectively). At these points in time, blood levels of cyclosporin A were also significantly lower. Other parameters of liver cell function and liver cell integrity (AP, AST, ALT, GLDH, total protein, thromboplastin time, partial thromboplastin time) were unchanged over time. Serial quantitative liver function tests (indocyanine green half-life, galactose elimination capacity, lidocaine half-life, and MEGX formation) also remained stable. Thus, we conclude that hepatic function remains stable in long-term survivors of liver transplantation for at least several years.
ISSN:0934-0874
1432-2277
DOI:10.1007/s001470050044