Genetic engineering of filamentous fungi

Filamentous fungi are important in medicine, industry, agriculture, and basic biological research. For example, some fungal species are pathogenic to humans, whereas others produce beta-lactam antibiotics (penicillin and cephalosporin). Industrial strains produce large amounts of enzymes, such as gl...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1989-06, Vol.244 (4910), p.1313-1317
Main Authors: Timberlake, W.E. (University of Georgia, Athens, GA.), Marshall, M.A
Format: Article
Language:English
Subjects:
Alleles
Aspergillus
ASPERGILLUS NIDULANS
Aspergillus nidulans - genetics
Biological and medical sciences
Biotechnological microorganisms
Biotechnology
CHAMPIGNON
Chromosomes
DNA
Drugs
Enzymes
Forecasting
Fundamental and applied biological sciences. Psychology
Fungi
Gene Expression Regulation
Genes
Genetic engineering
Genetic Engineering - methods
Genetic Engineering - trends
Genetic mutation
Genetic technics
Genetic transformation
Genetic vectors
Genetics
HONGOS
Methods
Methods. Procedures. Technologies
Microbial biotechnology
Molecular genetics
Mutation
Mycology
NEUROSPORA
Neurospora - genetics
Neurospora crassa - genetics
Penicillium
Plasmids
The New Harvest: Genetically Engineered Species
TRANSFERENCIA DE GENES
TRANSFERT DE GENE
TRANSFORMACION GENETICA
TRANSFORMATION GENETIQUE
Transformation, Genetic
Trichoderma
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Description
Summary:Filamentous fungi are important in medicine, industry, agriculture, and basic biological research. For example, some fungal species are pathogenic to humans, whereas others produce beta-lactam antibiotics (penicillin and cephalosporin). Industrial strains produce large amounts of enzymes, such as glucosamylose and proteases, and low molecular weight compounds, such as citric acid. The largest and most economically important group of plant pathogens are fungi. Several fungal species have biological properties and genetic systems that make them ideally suited for basic biological research. Recently developed techniques for genetic engineering of filamentous fungi make it possible to alter their detrimental and beneficial activities in novel ways
ISSN:0036-8075
1095-9203
DOI:10.1126/science.2525275