Effects of 72 hours sleep deprivation on wound healing in the rat

The purpose of this study was to examine effects of sleep deprivation on cellular and biochemical markers of wound healing. Expanded polytetrafluoroethylene tubing inserted in subcutaneous tissue created miniature wounds in the dorsal skin of 12 rats. Seven days later, 6 rats were deprived of sleep...

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Bibliographic Details
Published in:Research in nursing & health 1997-06, Vol.20 (3), p.259-267
Main Authors: Landis, Carol A., Whitney, JoAnne D.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biopsy
Dermatology
Disease Models, Animal
DNA - analysis
Fibroblasts - immunology
Granulocytes - immunology
Hydroxyproline - analysis
Macrophages - immunology
Male
Medical sciences
Nursing
platform method
Random Allocation
rat
Rats
Rats, Sprague-Dawley
Skin involvement in other diseases. Miscellaneous. General aspects
sleep deprivation
Sleep Deprivation - physiology
wound healing
Wound Healing - physiology
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Summary:The purpose of this study was to examine effects of sleep deprivation on cellular and biochemical markers of wound healing. Expanded polytetrafluoroethylene tubing inserted in subcutaneous tissue created miniature wounds in the dorsal skin of 12 rats. Seven days later, 6 rats were deprived of sleep by the platform method for 72 hr; control rats remained on usual sleep/wake routines. Numbers of macrophages, granulocytes, fibroblasts, and extent of connective tissue present and total amounts of protein, DNA, and hydroxyproline in the implants were not different between sleep‐deprived and control rats. There is no evidence from this study that sleep deprivation impairs cellular and biochemical indicators of tissue repair. © 1997 John Wiley & Sons, Inc. Res Nurs Health 20: 259–267, 1997
ISSN:0160-6891
1098-240X
DOI:10.1002/(SICI)1098-240X(199706)20:3<259::AID-NUR8>3.0.CO;2-H